首次使用大麻的原因与随后的大麻消费（标准四氢大麻酚单位）及精神病理学有关吗？
Are reasons for first using cannabis associated with subsequent cannabis consumption (standard THC units) and psychopathology?
作者信息
Spinazzola Edoardo, Degen Hannah, Austin-Zimmerman Isabelle, Trotta Giulia, Chesney Edward, Li Zhikun, Alameda Luis, Leung Bok Man, Lang Yifei, Quattrone Andrea, Quattrone Diego, Castrignanò Erika, Wolff Kim, Murray Robin, Freeman Tom P, Di Forti Marta
机构信息
Psychosis Studies, King's College London, London, UK
South London and Maudsley NHS Foundation Trust, London, UK.
出版信息
BMJ Ment Health. 2025 Aug 26;28(1):e301810. doi: 10.1136/bmjment-2025-301810.
BACKGROUND
Reasons for first using cannabis (RFUC) may influence later use patterns and mental health outcomes. However, limited research has explored self-medication versus social RFUCs in depth, and their associations with cannabis use patterns and psychopathology in the general population.
OBJECTIVES
We examined RFUCs and their associations with (1) reasons for continuing cannabis use, (2) weekly THC (delta-9-tetrahydrocannabinol) unit consumption and (3) symptoms of paranoia, anxiety and depressive symptoms.
METHODS
We analysed data from the Cannabis&Me (CAMe) population survey (March 2022-July 2024), including 2573 (75.9%) current and 816 (24.1%) past cannabis users aged 18 years or older.
FINDINGS
Participants reported a mean weekly consumption of 206 THC units (SD=268). Initiating cannabis use for anxiety (β=36.22, p=3.3e-03), depression (β=40.37, p=1.74e-03) or because 'family members were using it' (β=87.43, p=1.22e-09) was associated with higher weekly THC units. RFUC to relieve physical discomfort (β=8.89, p=4.12e-07), pain (β=7.24, p=5.56e-06), anxiety (β=9.67, p=1.63e-16), depression (β=9.12, p=1.21e-13) and minor psychotic symptoms (β=16.46, p=1.2e-04) were linked to higher paranoia scores. Similar associations were observed for anxiety and depression. Conversely, starting for fun (β=-3.71, p=3.49e-05) or curiosity (β=-2.61, p=5e-03) was associated with lower paranoia and anxiety. RFUC for 'boredom' was linked to increased depression (β=1.09, p=3.8e-03).
CONCLUSIONS
Initiating cannabis use for self-medication is associated with higher average THC consumption, and increased anxiety, depression and paranoia.
CLINICAL IMPLICATIONS
Asking individuals why they first used cannabis may serve as a cost-effective screening tool to identify those who could benefit from monitoring, support, or referral to intervention services.
背景
首次使用大麻的原因（RFUC）可能会影响后续的使用模式和心理健康结果。然而，有限的研究深入探讨了自我治疗与社交性首次使用大麻的原因，以及它们与普通人群中大麻使用模式和精神病理学的关联。
目的
我们研究了首次使用大麻的原因及其与（1）持续使用大麻的原因、（2）每周四氢大麻酚（THC，Δ⁹ - 四氢大麻酚）单位消费量和（3）偏执、焦虑和抑郁症状的关联。
方法
我们分析了“大麻与我”（CAMe）人群调查（2022年3月至2024年7月）的数据，包括2573名（75.9%）当前大麻使用者和816名（24.1%）过去的大麻使用者，年龄均在18岁及以上。
结果
参与者报告的每周平均四氢大麻酚消费量为206单位（标准差 = 268）。因焦虑（β = 36.22，p = 3.3×10⁻³）、抑郁（β = 40.37，p = 1.74×10⁻³）或“家庭成员在使用”（β = 87.43，p = 1.22×10⁻⁹）而开始使用大麻与每周更高的四氢大麻酚单位消费量相关。为缓解身体不适（β = 8.89，p = 4.12×10⁻⁷）、疼痛（β = 7.24，p = 5.56×10⁻⁶）、焦虑（β = 9.67，p = 1.63×10⁻¹⁶）、抑郁（β = 9.12，p = 1.21×10⁻¹³）和轻微精神病症状（β = 16.46，p = 1.2×10⁻⁴）而首次使用大麻与更高的偏执得分相关。焦虑和抑郁也观察到类似的关联。相反，因“好玩”（β = -3.71，p = 3.49×10⁻⁵）或“好奇”（β = -2.61，p = 5×10⁻³）而开始使用大麻与较低的偏执和焦虑相关。因“无聊”而首次使用大麻与抑郁增加（β = 1.09，p = 3.8×10⁻³）相关。
结论
因自我治疗而开始使用大麻与更高的平均四氢大麻酚消费量以及焦虑、抑郁和偏执增加有关。
临床意义
询问个体首次使用大麻的原因可能是一种经济有效的筛查工具，以识别那些可能从监测、支持或转介到干预服务中受益的人。
Zotero 插件