Zhu Yuqin, Mai Zhuoyao, Li Ruiqi, Liao Zaowen, Ouyang Nengyong, Chen Hui, Zhao Haijing
Reproductive Medicine Center, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China.
Reproductive Medicine Center, Shenshan Central Hospital, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Shanwei, Guangdong, China.
Front Reprod Health. 2025 Aug 8;7:1627160. doi: 10.3389/frph.2025.1627160. eCollection 2025.
Recurrent spontaneous abortion (RSA), characterized by the occurrence of three or more pregnancy losses prior to the 28th week of gestation, stands as a formidable challenge in the realm of assisted reproductive medicine, presenting significant difficulties in both clinical diagnosis and treatment. In recent years, there has been a discernible upward trend in the incidence of RSA, and its etiology is multifaceted and intricate. Pinpointing the root causes of RSA remains an arduous task that urgently demands resolution within the field of reproductive medicine. Through a comprehensive and in-depth analysis of the RSA-related case report, embryonic chromosomal abnormalities were identified as the highest-risk factor. Utilizing preimplantation genetic testing for aneuploidy (PGT-A) technology, an euploid blastocyst was selected for transfer, which led to successful pregnancy and healthy birth. This case holds significant reference value for the clinical treatment of RSA.
复发性自然流产(RSA)的特征是在妊娠28周前发生三次或更多次妊娠丢失,这在辅助生殖医学领域是一个巨大的挑战,在临床诊断和治疗方面都存在重大困难。近年来,RSA的发病率有明显上升趋势,其病因是多方面且错综复杂的。确定RSA的根本原因仍然是生殖医学领域一项迫切需要解决的艰巨任务。通过对一份与RSA相关的病例报告进行全面深入分析,发现胚胎染色体异常是最高风险因素。利用胚胎植入前非整倍体基因检测(PGT-A)技术,选择了一个整倍体囊胚进行移植,最终成功妊娠并顺利分娩。该病例对RSA的临床治疗具有重要参考价值。