Pedroni Lorenzo, Dall'Asta Chiara, Galaverna Gianni, Dellafiora Luca
Department of Food and Drug University of Parma Parco Area delle Scienze 27/A Parma 43124 Italy.
Glob Chall. 2025 Jul 2;9(8):e00051. doi: 10.1002/gch2.202500051. eCollection 2025 Aug.
The concept of mirror life is first introduced by Louis Pasteur, referring to biological systems composed of enantiomeric biomolecules. Although nowadays technologies are making a mirror life theoretically achievable, its potential risks remain uncertain. Here, an integrated multi-tier computational pipeline is employed to address the potential environmental threat posed by the hypothetical mirror-image of , a bacterium relevant to environmental and food safety. The findings suggest that amoxicillin, and perhaps other conventional antibiotics, should not be effective against their mirror targets. On the other hand, the enantiomeric amoxicillin may be a successful counteracting measure, although the risks for the biosphere remain unknown. Overall, this study highlights the need for further dedicated investigations in this field, while emphasizing methods, in particular molecular modeling, as a versatile and effective first-line approach for analysis, free from biohazards and technical limitations of reagents supply.
镜像生命的概念最早由路易·巴斯德提出，指的是由对映体生物分子组成的生物系统。尽管如今的技术使镜像生命在理论上成为可能，但其潜在风险仍不确定。在此，我们采用了一个集成的多层计算流程，以应对一种与环境和食品安全相关的细菌的假设镜像所带来的潜在环境威胁。研究结果表明，阿莫西林以及其他一些传统抗生素可能对其镜像靶点无效。另一方面，对映体阿莫西林可能是一种成功的应对措施，尽管其对生物圈的风险仍未知。总体而言，本研究强调了该领域进一步专项研究的必要性，同时强调了相关方法，特别是分子建模，作为一种通用且有效的一线分析方法的重要性，它不受生物危害和试剂供应技术限制的影响。
