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通过代谢组学和转录组学揭示扫日劳 - 4汤治疗肺纤维化的机制

Unveiling the therapeutic mechanisms of Saorilao-4 decoction in pulmonary fibrosis through metabolomics and transcriptomics.

作者信息

Liu Jiali, Song Xiaowen, Song Xinni, Fu Xinyue, Niu Shufang, Chang Hong, Shi Songli, Yang Meiqing, Zhao Ruiqi, Wang Peng, Qi Jun, Bai Wanfu

机构信息

Department of Pharmacy, Baotou Medical College, Baotou, China.

The Second Affiliated Hospital of Baotou Medical College, Baotou, China.

出版信息

Front Nutr. 2025 Aug 11;12:1612149. doi: 10.3389/fnut.2025.1612149. eCollection 2025.

DOI:10.3389/fnut.2025.1612149
PMID:40860474
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12375468/
Abstract

Pulmonary fibrosis (PF) is a challenging and intricate lung ailment to treat. Saorilao-4 decoction (SRL) is a traditional Mongolian medicine remedy frequently utilized in the management of lung disorders. This study employed transcriptomics and metabolomics to explore the molecular mechanisms of SRL in the bleomycin-induced PF rat model. Additionally, histopathological analysis and the assessment of serum biochemical indices were utilized to investigate the potential mitigating effects of SRL on PF. Transcriptomics and metabolomics analyses indicate that SRL primarily modulates the adenosine monophosphate-activated protein kinase (AMPK) and peroxisome proliferator-activated receptors (PPAR) signaling pathways by regulating genes such as , , , , , and . Thereby influencing biomarkers such as S-Adenosylmethioninamine (SAM), 16-hydroxyhexadecanoic acid, and proline, mitigating metabolic disorders in pathways such as arginine and proline metabolism, vitamin B6 metabolism, fatty acid degradation, and arachidonic acid metabolism. The present study reveals the regulation of unsaturated fatty acid-related metabolic pathways and elucidates the mechanism of action of SRL in ameliorating PF.

摘要

肺纤维化（PF）是一种治疗起来具有挑战性且复杂的肺部疾病。扫日劳 - 4汤（SRL）是一种常用于治疗肺部疾病的传统蒙药。本研究采用转录组学和代谢组学方法，探究SRL在博来霉素诱导的PF大鼠模型中的分子机制。此外，利用组织病理学分析和血清生化指标评估，研究SRL对PF的潜在缓解作用。转录组学和代谢组学分析表明，SRL主要通过调节 、 、 、 、 、 等基因，调控腺苷单磷酸激活的蛋白激酶（AMPK）和过氧化物酶体增殖物激活受体（PPAR）信号通路。从而影响S - 腺苷甲硫氨酸胺（SAM）、16 - 羟基十六烷酸和脯氨酸等生物标志物，减轻精氨酸和脯氨酸代谢、维生素B6代谢、脂肪酸降解和花生四烯酸代谢等途径中的代谢紊乱。本研究揭示了不饱和脂肪酸相关代谢途径的调控情况，阐明了SRL改善PF的作用机制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/68ee/12375468/2bdea4bd7cb5/fnut-12-1612149-g007.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/68ee/12375468/35d9f06f5ab9/fnut-12-1612149-g001.jpg
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LncRNA-mediated ceRNA network reveals the mechanism of action of Saorilao-4 decoction against pulmonary fibrosis.
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Front Genet. 2024 Mar 12;15:1339064. doi: 10.3389/fgene.2024.1339064. eCollection 2024.
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