Che Lah Muhammad Hanif, Faruque Reza Mohammed, Shamsuddin Shaharum, Watanabe Isao, Abdullah Jafri M
Department of Neurosciences, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia.
Meson Science Laboratory, RIKEN Nishina Center, Institute of Physical and Chemical Research (RIKEN), Wako, Saitama, Japan.
PeerJ. 2025 Aug 20;13:e19807. doi: 10.7717/peerj.19807. eCollection 2025.
Parkinson's disease (PD) is the most typical neurological disorder associated with aging in humans. Since PD has much to do with the medical field, most research studies focus on the biological, chemical, and medical aspects of the investigations, in addition to epidemiological studies, drug intervention studies, and much more. The lack of studies using scanning tunneling microscopy (STM) to investigate the electron transfer properties of DNA in PD opens up a new opportunity to look at electron transfer, which is fundamental to understanding the biological processes of the damage-repair mechanism of DNA in this disease, from a physical perspective. Hence, this systematic review was conducted to identify the methods or techniques currently used in the medical-related fields to study electron transfer in PD. related to electron transfer and PD.
Scopus, ScienceDirect, and EBSCOhost MEDLINE databases were used to search for literature related to electron transfer and PD.
From the thirty studies identified, PD appears to be caused by various causes, including increased levels of cytochrome c, reactive oxygen species produced by the mitochondria, dysfunction of complex I that interferes with the electron transfer process, and mitochondrial dysfunction triggered by PINK1 mutation. 6.7% of prior research has focused on utilizing DNA as a specific sample for investigating electron transfer in synthetic DNA through the use of STM. This highlights a notable lack of research into the potential of DNA in PD, despite the theoretical advantages that STM offers.
We propose using STM as a new technique to study electron transfer in the DNA of PD from the physics perspective.
帕金森病（PD）是人类与衰老相关的最典型神经疾病。由于帕金森病与医学领域密切相关，除了流行病学研究、药物干预研究等之外，大多数研究都集中在生物学、化学和医学方面的调查。缺乏使用扫描隧道显微镜（STM）研究帕金森病中DNA电子转移特性的研究，这为从物理角度研究电子转移提供了新机会，而电子转移对于理解该疾病中DNA损伤修复机制的生物学过程至关重要。因此，进行了这项系统综述，以确定医学相关领域目前用于研究帕金森病中电子转移的方法或技术。与电子转移和帕金森病相关。
使用Scopus、ScienceDirect和EBSCOhost MEDLINE数据库搜索与电子转移和帕金森病相关的文献。
在确定的30项研究中，帕金森病似乎由多种原因引起，包括细胞色素c水平升高、线粒体产生的活性氧、干扰电子转移过程的复合体I功能障碍以及由PINK1突变引发的线粒体功能障碍。6.7%的先前研究集中于通过使用STM将DNA作为特定样本用于研究合成DNA中的电子转移。这突出表明，尽管STM具有理论优势，但对帕金森病中DNA潜力的研究明显不足。
我们建议将STM作为一种新技术，从物理学角度研究帕金森病DNA中的电子转移。
