Liu Jun, Zhang Wenjun, Huang Qianliang, Ye Xinyun, Huang Guanlin
Department of Neurosurgery, the 2nd Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China.
Department of Neurosurgery, The Ganzhou Affiliated Hospital, Jiangxi Medical College, Nanchang University, Ganzhou, Jiangxi, China.
Front Oncol. 2025 Aug 11;15:1490783. doi: 10.3389/fonc.2025.1490783. eCollection 2025.
To investigate the clinical characteristics and therapeutic approaches for granular cell tumors (GCT) of the neurohypophysis.
Retrospective case series and analyzed the clinical data of six patients with histopathologically confirmed GCT of the neurohypophysis, also conducting a simple review of relevant literature.
The median age at diagnosis for the cohort of six patients was 41.0 ± 11.73 years, with an age range of 21.8 to 52.7 years. A predominance of female patients was noted, accounting for five out of six cases. The most common clinical symptoms were headache and visual disturbances, each reported in five of the six patients. Magnetic resonance imaging (MRI) of the brain predominantly revealed a rounded morphology, and well-defined boundaries. Of these tumors, two were located in the suprasellar region while four were situated within the sellar region, encompassing intrasellar, suprasellar, and parasellar locations. Contrast-enhanced MRI demonstrated heterogeneous enhancement in four cases and homogeneous enhancement in two cases. Surgical intervention, either through a neuro-endoscopic endonasal transsphenoidal approach or craniotomy, achieved total or subtotal tumor resection in all patients. Postoperative histopathological examination confirmed the diagnosis of GCT in each instance. All patients participated in follow-up evaluations, during which varying degrees of clinical symptom improvement were documented. Importantly, none of the four patients who underwent complete tumor resection exhibited recurrence or metastasis.
GCT of the neurohypophysis are rarely encountered clinical practice. The definitive diagnosis of GCT primarily relies on histopathological evaluation. Currently, the standard therapeutic approach involves complete surgical excision of the tumor using a neuroendoscopic endonasal transsphenoidal technique. Post-resection, the rates of recurrence and metastasis are significantly low.
探讨神经垂体颗粒细胞瘤（GCT）的临床特征及治疗方法。
回顾性病例系列研究，分析6例经组织病理学确诊的神经垂体GCT患者的临床资料，并对相关文献进行简要综述。
6例患者队列的诊断中位年龄为41.0±11.73岁，年龄范围为21.8至52.7岁。女性患者占优势，6例中有5例。最常见的临床症状是头痛和视力障碍，6例患者中有5例报告了这两种症状。脑部磁共振成像（MRI）主要显示为圆形形态，边界清晰。其中2例位于鞍上区，4例位于鞍内区，包括鞍内、鞍上和鞍旁位置。增强MRI显示4例不均匀强化，2例均匀强化。通过神经内镜鼻内经蝶窦入路或开颅手术进行手术干预，所有患者均实现了肿瘤全切除或次全切除。术后组织病理学检查在每个病例中均确诊为GCT。所有患者均参与了随访评估，在此期间记录到不同程度的临床症状改善。重要的是，4例肿瘤完全切除的患者均未出现复发或转移。
神经垂体GCT在临床实践中很少见。GCT的明确诊断主要依靠组织病理学评估。目前，标准的治疗方法是使用神经内镜鼻内经蝶窦技术完全切除肿瘤。切除术后，复发和转移率显著较低。
