Mohan Akhil, Kannoth Prakasan, Unni Chandramohan, Jose Byjo Valiyaveetil, Parambil Rajeev Mandaka, Nandeesh B N
Department of Neurosurgery, Government Medical College, Kozhikode, Kerala, India.
Department of Neuropathology, National Institute of Mental Health and Neurosciences, Bengaluru, India.
Surg Neurol Int. 2020 Aug 29;11:261. doi: 10.25259/SNI_316_2020. eCollection 2020.
Granular cell tumors (GCTs) of the pituitary are rare tumors of posterior pituitary that can present as giant pituitary macroadenoma due to the slow indolent growth of the tumor. We are reporting this case due to the rarity of GCT and usually these tumors are confined to the suprasellar region since they are arising from the pituitary stalk. GCTs that attain such giant size with cavernous sinus invasion are still rarer.
A 38-year-old female who presented with progressive deterioration of vision and on evaluation by magnetic resonance imaging showed a giant pituitary macroadenoma with bilateral cavernous sinus invasion. The patient underwent pterional craniotomy and near-total excision of the lesion was done due to high vascularity and firmness of the tumor. Histopathology examination of the lesion showed spindle to globular cells with granular cytoplasm and was reported as GCT of the pituitary.
GCTs are WHO grade1 non-neuroendocrine tumors arising from neurohypophysis and infundibulum. Complete excision is usually difficult due to the high vascularity, firm consistency, and local invasion of the tumor to the cavernous sinus and optic apparatus.
垂体颗粒细胞瘤（GCTs）是一种罕见的垂体后叶肿瘤，由于肿瘤生长缓慢，可表现为巨大垂体大腺瘤。我们报告此病例是因为GCT罕见，且这些肿瘤通常局限于鞍上区域，因为它们起源于垂体柄。侵袭海绵窦并达到如此巨大尺寸的GCT更为罕见。
一名38岁女性，视力进行性恶化，磁共振成像评估显示为巨大垂体大腺瘤，双侧海绵窦受侵。患者接受了翼点开颅手术，由于肿瘤血管丰富且质地坚硬，对病变进行了近全切除。病变的组织病理学检查显示为梭形至球形细胞，细胞质呈颗粒状，报告为垂体GCT。
GCT是世界卫生组织1级非神经内分泌肿瘤，起源于神经垂体和漏斗部。由于肿瘤血管丰富、质地坚硬以及局部侵犯海绵窦和视器，通常难以完全切除。
