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Dysfunction of monocyte in the development of HBV-ACLF: Immune activation or immune suppression?

作者信息

Shen Yangfan, Wu Xiaoxin, Xu Xiaowei

机构信息

State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Centre for Infectious Diseases, Collaborative Innovation Centre for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China.

出版信息

J Transl Int Med. 2025 Jul 30;13(4):308-310. doi: 10.1515/jtim-2025-0014. eCollection 2025 Aug.

DOI:10.1515/jtim-2025-0014
PMID:40861066
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12371393/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a5d6/12371393/257f9606a3f8/j_jtim-2025-0014_fig_001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a5d6/12371393/257f9606a3f8/j_jtim-2025-0014_fig_001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a5d6/12371393/257f9606a3f8/j_jtim-2025-0014_fig_001.jpg

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本文引用的文献

1
CCR2+TREM-1+ monocytes promote natural killer T cell dysfunction contributing towards HBV disease progression.CCR2+TREM-1+单核细胞促进自然杀伤 T 细胞功能障碍，导致 HBV 疾病进展。
Immunol Res. 2024 Oct;72(5):938-947. doi: 10.1007/s12026-024-09495-4. Epub 2024 May 30.
2
Distinct immunometabolic signatures in circulating immune cells define disease outcome in acute-on-chronic liver failure.循环免疫细胞中独特的免疫代谢特征决定了慢加急性肝衰竭的疾病转归。
Hepatology. 2025 Feb 1;81(2):509-522. doi: 10.1097/HEP.0000000000000907. Epub 2024 May 16.
3
Intrahepatic macrophage reprogramming associated with lipid metabolism in hepatitis B virus-related acute-on-chronic liver failure.
乙型肝炎病毒相关慢加急性肝衰竭中与脂质代谢相关的肝内巨噬细胞重编程。
J Transl Med. 2023 Jun 28;21(1):419. doi: 10.1186/s12967-023-04294-1.
4
Genetic landscape and immune mechanism of monocytes associated with the progression of acute-on-chronic liver failure.与慢加急性肝衰竭进展相关的单核细胞的遗传特征和免疫机制。
Hepatol Int. 2023 Jun;17(3):676-688. doi: 10.1007/s12072-022-10472-y. Epub 2023 Jan 10.
5
PBMC transcriptomics identifies immune-metabolism disorder during the development of HBV-ACLF.PBMC 转录组学鉴定 HBV-ACLF 发展过程中的免疫代谢紊乱。
Gut. 2022 Jan;71(1):163-175. doi: 10.1136/gutjnl-2020-323395. Epub 2021 Jan 11.
6
Inhibition of glutamine synthetase in monocytes from patients with acute-on-chronic liver failure resuscitates their antibacterial and inflammatory capacity.在慢性肝衰竭急性发作患者的单核细胞中抑制谷氨酰胺合成酶可恢复其抗菌和炎症能力。
Gut. 2019 Oct;68(10):1872-1883. doi: 10.1136/gutjnl-2018-316888. Epub 2018 Dec 22.
7
DAMP molecular IL-33 augments monocytic inflammatory storm in hepatitis B-precipitated acute-on-chronic liver failure.DAMP 分子 IL-33 增强乙型肝炎诱发的慢加急性肝衰竭中的单核细胞炎症风暴。
Liver Int. 2018 Feb;38(2):229-238. doi: 10.1111/liv.13503. Epub 2017 Jul 20.
8
CD14 CD15 HLA-DR myeloid-derived suppressor cells impair antimicrobial responses in patients with acute-on-chronic liver failure.CD14+CD15+HLA-DR 髓系来源抑制细胞损害慢加急性肝衰竭患者的抗菌反应。
Gut. 2018 Jun;67(6):1155-1167. doi: 10.1136/gutjnl-2017-314184. Epub 2017 Jun 7.
9
The Pathogenesis of ACLF: The Inflammatory Response and Immune Function.急性肝衰竭的发病机制：炎症反应与免疫功能
Semin Liver Dis. 2016 May;36(2):133-40. doi: 10.1055/s-0036-1583199. Epub 2016 May 12.
10
Patients with acute-on-chronic liver failure have increased numbers of regulatory immune cells expressing the receptor tyrosine kinase MERTK.伴有慢加急性肝衰竭的患者具有表达受体酪氨酸激酶 MERTK 的调节性免疫细胞增多。
Gastroenterology. 2015 Mar;148(3):603-615.e14. doi: 10.1053/j.gastro.2014.11.045. Epub 2014 Dec 3.