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青年男性与青年女性大脑之间的局部一致性差异：一项静息态功能磁共振成像研究。

Regional homogeneity differences between the brains of young men and young women: A resting-state functional magnetic resonance imaging study.

作者信息

Li Xiaoci, Sun Lingling, Zeng Ziyu, Yan Shihong, Rui Abao, Cai Jian, Wang Qingyu, Mei Jian, Yu Yun, Yu Yue

机构信息

Yizheng Hospital of Traditional Chinese Medicine, Yizheng, Jiangsu 211400, China.

School of Pediatrics, Nanjing Medical University, Nanjing, Jiangsu 211166, China.

出版信息

IBRO Neurosci Rep. 2025 Aug 12;19:417-425. doi: 10.1016/j.ibneur.2025.08.006. eCollection 2025 Dec.

DOI:10.1016/j.ibneur.2025.08.006
PMID:40861248
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12375249/
Abstract

OBJECTIVE

The aim of the study was to investigate gender differences in the brains of young healthy adults, by calculating the regional homogeneity (ReHo) values of resting-state functional magnetic resonance imaging (rs-fMRI). Thereby providing candidate imaging biomarkers for risk stratification of neurodegenerative diseases and offering a basis for their early screening and targeted intervention.

METHODS

Forty-two (42) healthy young adults (21males and 21females) were examined using resting-state fMRI. We employed the statistical method of regional homogeneity (ReHo) to compare the brains of males and females.

RESULTS

The female group exhibited higher activity intensity in the right supramarginal gyrus, but significantly lower activity intensity in the left dorsolateral prefrontal cortex, the right frontal eye field, the right premotor cortex and the right superior temporal gyrus compared to the male group.

CONCLUSION

Males have greater advantages in working memory, conscious decision-making behavior, visual-motor skills, physical reaction speed, rhythmic perception and language perception, while females show better episodic memory and visual imagination. High ReHo in the left DLPFC of men is a screening marker for high-risk groups of men with AD. High ReHo in the right superior marginal gyrus of women is an early warning biomarker for PTSD or depression.

摘要

目的

本研究旨在通过计算静息态功能磁共振成像（rs-fMRI）的局部一致性（ReHo）值，调查年轻健康成年人脑内的性别差异。从而为神经退行性疾病的风险分层提供候选成像生物标志物，并为其早期筛查和靶向干预提供依据。

方法

对42名健康年轻成年人（21名男性和21名女性）进行静息态功能磁共振成像检查。我们采用局部一致性（ReHo）统计方法比较男性和女性的大脑。

结果

与男性组相比，女性组在右侧缘上回表现出更高的活动强度，但在左侧背外侧前额叶皮层、右侧额眼区、右侧运动前区皮层和右侧颞上回的活动强度显著更低。

结论

男性在工作记忆、有意识决策行为、视觉运动技能、身体反应速度、节奏感知和语言感知方面具有更大优势，而女性则表现出更好的情景记忆和视觉想象力。男性左侧背外侧前额叶皮层的高ReHo是男性阿尔茨海默病高危人群的筛查标志物。女性右侧缘上回的高ReHo是创伤后应激障碍或抑郁症的早期预警生物标志物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2ef/12375249/ad6e6e0d0e91/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2ef/12375249/e444da3ee80a/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2ef/12375249/0f57c5bc01da/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2ef/12375249/54b133822005/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2ef/12375249/7ebcdda6a594/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2ef/12375249/f84fe59a1530/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2ef/12375249/ad6e6e0d0e91/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2ef/12375249/e444da3ee80a/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2ef/12375249/0f57c5bc01da/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2ef/12375249/54b133822005/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2ef/12375249/7ebcdda6a594/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2ef/12375249/f84fe59a1530/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2ef/12375249/ad6e6e0d0e91/gr6.jpg

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