Nudo Randolph J, McNeal David
Department of Molecular and Integrative Physiology, KU Medical Center, Kansas City, KS, USA.
Handb Clin Neurol. 2013;110:13-21. doi: 10.1016/B978-0-444-52901-5.00002-2.
Over the past two decades, results from neurophysiological studies in animal models and neuroimaging studies in human populations have converged along a common thread. Neuroplasticity in the remaining, intact tissue accompanies functional recovery after brain injury. Now, virtually every new therapeutic approach in postinjury rehabilitation relies on the fundamental principles of neuroplasticity for theoretical validity. In this chapter, the basic tenets of plasticity are outlined, and the neural substrates in the cerebral cortex that may subserve recovered functions are reviewed.
在过去二十年中，动物模型的神经生理学研究结果与人类群体的神经影像学研究结果殊途同归。脑损伤后，剩余完整组织中的神经可塑性伴随着功能恢复。如今，损伤后康复领域几乎每一种新的治疗方法都依赖于神经可塑性的基本原理来确保理论有效性。在本章中，我们将概述可塑性的基本原理，并综述大脑皮层中可能支持功能恢复的神经基质。
