利用氯化锂实现烯胺酮的氧化自由基C(sp)-H键氯化反应：合成高度官能化的α-氯化烯胺酮
Oxidative Free-Radical C(sp)-H Bond Chlorination of Enaminones with LiCl: Access to Highly Functionalized α-Chlorinated Enaminones.
作者信息
Xie Yunhua, Zhang Zhilai, Zhang Biao, He Nengqin, Peng Menglin, Song Siyu, Wang Baoqu, Yu Fuchao
机构信息
Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, P. R. China.
Yunnan Key Laboratory for Pollution Processes and Control of Plateau Lake-Watersheds, Yunnan Academy of Ecological and Environmental Sciences, Kunming 650500, P. R. China.
出版信息
J Org Chem. 2024 Jun 21;89(12):8521-8530. doi: 10.1021/acs.joc.4c00456. Epub 2024 Jun 3.
An oxidative free-radical C(sp)-H bond chlorination strategy of enaminones has been developed by using LiCl as a chlorinating reagent and KSO as an oxidant. This transformation provides a new and straightforward synthetic methodology to afford highly functionalized α-chlorinated enaminones with a -configuration in good to excellent yields.
通过使用LiCl作为氯化试剂、KSO作为氧化剂，开发了一种烯胺酮的氧化自由基C(sp)-H键氯化策略。该转化提供了一种新的直接合成方法，能够以良好至优异的产率得到具有α-构型的高度官能化的α-氯化烯胺酮。
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