Center for Depression Research and Clinical Care, Peter O'Donnell Jr. Brain Institute and Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Center for Depression Research and Clinical Care, Peter O'Donnell Jr. Brain Institute and Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA; Peter O'Donnell Jr. School of Public Health, University of Texas Southwestern Medical Center, Dallas, TX, USA.
J Affect Disord. 2023 Nov 1;340:88-99. doi: 10.1016/j.jad.2023.07.035. Epub 2023 Jul 17.
American youth are seriously impacted by depression and suicide. The Texas Youth Depression and Suicide Research Network (TX-YDSRN) Participant Registry Study was initiated in 2020 to develop predictive models for treatment outcomes in youth with depression and/or suicidality. This report presents the study rationale, design and baseline characteristics of the first 1000 participants.
TX-YDSRN consists of the Network Hub (coordinating center), 12 medical school "Nodes" (manage/implement study), each with 1-5 primary care, inpatient, and/or outpatient Sub-Sites (recruitment, data collection). Participants are 8-20-year-olds who receive treatment or screen positive for depression and/or suicidality. Baseline data include mood and suicidality symptoms, associated comorbidities, treatment history, services used, and social determinants of health. Subsequent assessments occur every two months for 24 months.
Among 1000 participants, 68.7 % were 12-17 years, 24.6 % were ≥ 18 years, and 6.7 % were < 12. Overall, 36.8 % were non-Hispanic Caucasian, 73.4 % were female, and 79.9 % had a primary depressive disorder. Nearly half of the sample reported ≥1 suicide attempt, with rates similar in youth 12-17 years old (49.9 %) and those 18 years and older (45.5 %); 29.9 % of children <12 reported at least one suicide attempt. Depression and anxiety scores were in the moderate-severe range for all age groups (Patient Health Questionnaire for Adolescents [PHQ-A]: 12.9 ± 6.4; Generalized Anxiety Disorder [GAD-7]: 11.3 ± 5.9).
The sample includes youth who are receiving depression care at enrollment and may not be representative of non-diagnosed, non-treatment seeking youth.
The TX-YDSRN is one of the largest prospective longitudinal cohort registries designed to develop predictive models for outcome trajectories based on disorder heterogeneity, social determinants of health, and treatment availability.
美国青少年深受抑郁和自杀问题的影响。德克萨斯州青少年抑郁和自杀研究网络（TX-YDSRN）参与者注册研究于 2020 年启动，旨在为患有抑郁和/或自杀倾向的青少年的治疗结果开发预测模型。本报告介绍了该研究的基本原理、设计和前 1000 名参与者的基线特征。
TX-YDSRN 由网络中心（协调中心）和 12 个医学院“节点”（管理/实施研究）组成，每个节点都有 1-5 个初级保健、住院和/或门诊分站点（招募、数据收集）。参与者为 8-20 岁，接受治疗或筛查出患有抑郁和/或自杀倾向。基线数据包括情绪和自杀症状、相关合并症、治疗史、使用的服务以及健康的社会决定因素。随后每两个月评估一次，共 24 个月。
在 1000 名参与者中，68.7%为 12-17 岁，24.6%为≥18 岁，6.7%为<12 岁。总体而言，36.8%为非西班牙裔白种人，73.4%为女性，79.9%患有原发性抑郁症。近一半的样本报告至少有一次自杀企图，12-17 岁的青少年（49.9%）和 18 岁及以上的青少年（45.5%）的自杀企图率相似；29.9%的<12 岁儿童报告至少有一次自杀企图。所有年龄组的抑郁和焦虑评分均处于中重度范围（青少年患者健康问卷 [PHQ-A]：12.9±6.4；广泛性焦虑障碍 [GAD-7]：11.3±5.9）。
该样本包括在入组时正在接受抑郁治疗的青少年，可能无法代表未确诊、未寻求治疗的青少年。
TX-YDSRN 是最大的前瞻性纵向队列注册之一，旨在根据疾病异质性、健康的社会决定因素和治疗可用性，为结局轨迹开发预测模型。
