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茶剂形式的米曲菌治疗剂的体外抗氧化特性及对Wistar大鼠甲醇诱导的氧化应激的体内保护作用

In Vitro Antioxidant Properties of Mitratonic Remedy in Tea Form and In Vivo Protection Against Methanol-Induced Oxidative Stress in Wistar Rats.

作者信息

Issuriya Acharaporn, Sanpinit Sineenart, Limsuwan Surasak, Goon Jo Aan, Wetchakul Palika

机构信息

Division of Health and Applied Sciences, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla 90110, Thailand.

Division of Applied Thai Traditional Medicine, School of Medicine, Walailak University, Thasala, Nakhon Si Thammarat 80160, Thailand.

出版信息

Scientifica (Cairo). 2025 Aug 18;2025:9944914. doi: 10.1155/sci5/9944914. eCollection 2025.

DOI:10.1155/sci5/9944914
PMID:40861930
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12377970/
Abstract

Natural healthcare products with antiaging properties are attracting growing interest, and Thailand has a rich tradition of using herbal remedies for disease treatment and overall well-being. Mitra tea, derived from the traditional Mitratonic Remedy, is a Thai herbal formulation that has been used by local traditional healers for over 20 years and is officially recognized by the Department of Thai Traditional and Alternative Medicine, Ministry of Public Health, Thailand. Traditionally, it has been used to promote vitality, strengthen the body, and support longevity. However, scientific evidence supporting these traditional claims remains limited. Therefore, this study aimed to investigate the potential of Mitratonic Remedy in the form of herbal tea, herein referred to as Mitra tea. This study evaluated the antioxidant activity of Mitra tea through various antioxidant in vitro assays and analysis, alongside an in vivo male Wistar rats model with induced oxidative stress. Results demonstrated remarkably strong antioxidant properties, with notable DPPH scavenging activity (0.40 mg/mL) and high ferric-reducing antioxidant power (FRAP: 2551.95 mM FeSO equivalent/mg sample). Additionally, Mitra tea exhibited exceptional phenolic (142.76 mg/g) and flavonoid content (11,432.34 mg/g), further reinforcing its bioactive potential. In vivo findings revealed its ability to reduce MDA levels while enhancing key antioxidant enzymes, suggesting its effectiveness in mitigating oxidative stress. With its significant antioxidant properties and potential health benefits, Mitra tea stands out as a promising natural healthcare solution for antiaging product development, offering a scientifically backed alternative for consumers seeking longevity and wellness.

摘要

具有抗衰老特性的天然保健品正吸引着越来越多的关注,泰国有着使用草药疗法治疗疾病和促进整体健康的丰富传统。米特拉茶源自传统的米特拉通疗法,是一种泰国草药配方,当地传统治疗师已使用了20多年,并得到泰国公共卫生部泰国传统与替代医学司的官方认可。传统上,它被用于促进活力、增强体质和延年益寿。然而,支持这些传统说法的科学证据仍然有限。因此,本研究旨在调查草药茶形式的米特拉通疗法(以下简称米特拉茶)的潜力。本研究通过各种体外抗氧化试验和分析评估了米特拉茶的抗氧化活性,并以体内雄性Wistar大鼠诱导氧化应激模型进行研究。结果表明其具有非常强的抗氧化性能,具有显著的DPPH清除活性(0.40mg/mL)和高铁还原抗氧化能力(FRAP:2551.95mM硫酸亚铁当量/毫克样品)。此外,米特拉茶表现出优异的酚类(142.76mg/g)和黄酮类含量(11432.34mg/g),进一步增强了其生物活性潜力。体内研究结果显示其能够降低丙二醛水平,同时增强关键抗氧化酶,表明其在减轻氧化应激方面的有效性。凭借其显著的抗氧化性能和潜在的健康益处,米特拉茶作为抗衰老产品开发的一种有前途的天然保健解决方案脱颖而出,为寻求长寿和健康的消费者提供了一种有科学依据的选择。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c161/12377970/f644caf13a1e/SCIENTIFICA2025-9944914.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c161/12377970/5bf886a97c9b/SCIENTIFICA2025-9944914.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c161/12377970/f644caf13a1e/SCIENTIFICA2025-9944914.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c161/12377970/5bf886a97c9b/SCIENTIFICA2025-9944914.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c161/12377970/f644caf13a1e/SCIENTIFICA2025-9944914.002.jpg

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