Effect of vitamin A on hepatic microsomal drug metabolising enzymes activity in rats exposed to acute hypoxia.

The hepatic drug metabolising enzymes activity has been studied in rats exposed to acute hypoxia alone or along with supplementation of single dose of 10 000 I.U. Vitamin A. Hypoxic stress reduces the activities of cytochrome P-450, cytochrome c-reductase and aniline hydroxylase. Administration of single dose of 10 000 I.U. of Vitamin A to the rats 12 h before hypoxia reverses the effect of hypoxia on these enzymes. Thus Vitamin A seems to play a protective role in rats exposed to hypoxia on the activity of MFO system.