Powell Claire, Peeren Siofra, Ostrowska Ania, Adil Shehzore, Botevyle Jamie, Chesters Heather, Wolstencroft Jeanne, Yapp Emma, Feder Gene, Gilbert Ruth, Howarth Emma
Institute of Child Health, UCL, 30 Guilford St, WC1N 1EH London, UK.
Service User Research Enterprise, King's College London, 18 De Crespigny Park, SE5 8AF London, UK.
J Fam Violence. 2025;40(6):1245-1252. doi: 10.1007/s10896-023-00662-z. Epub 2023 Oct 31.
Core Outcome Sets (COS) are agreed sets of outcomes to be used in all trials that evaluate the effect of interventions. This report considers the added value of including grey and qualitative literature in a study to identify COSs of family-focused interventions for CM and DVA.
We identified outcomes of interventions for DVA or CM through systematically searching 12 academic databases and 86 organisation websites, leading to the inclusion of 485 full-text reports across 6 reviews. We developed a candidate outcome longlist comprising 347 extracted outcomes.
We identified 87% (282/347) of candidate outcomes from the grey and qualitative literature, and 37% (127/347) from the trial literature. Of the candidate outcomes on the longlist, 22% (75/347) were identified solely from the grey or qualitative literature and 7% (26/347) from trial literature. Three of the eight outcomes in the final core outcome sets may have been missed if grey or qualitative literature had not been searched.
The qualitative and grey literature adds DVA and CM outcomes that are relevant to survivor perspectives but not reported in trials; this had an impact on the final COSs. It is important for COS developers to consider what they may be missing if they do not search the qualitative and grey literature.
核心结局集（COS）是在所有评估干预措施效果的试验中使用的商定结局集。本报告探讨了在一项研究中纳入灰色文献和定性文献以确定针对慢性疾病（CM）和家庭暴力（DVA）的以家庭为中心的干预措施的核心结局集的附加价值。
我们通过系统检索12个学术数据库和86个组织网站，确定了针对DVA或CM的干预措施的结局，共纳入6篇综述中的485篇全文报告。我们制定了一份包含347个提取结局的候选结局长名单。
我们从灰色文献和定性文献中确定了87%（282/347）的候选结局，从试验文献中确定了37%（127/347）的候选结局。在长名单上的候选结局中，22%（75/347）仅从灰色文献或定性文献中确定，7%（26/347）从试验文献中确定。如果未检索灰色文献或定性文献，最终核心结局集中的八个结局中的三个可能会被遗漏。
定性文献和灰色文献增加了与幸存者观点相关但未在试验中报告的DVA和CM结局；这对最终的核心结局集产生了影响。对于核心结局集开发者来说，重要的是要考虑如果不检索定性文献和灰色文献可能会遗漏什么。
