Department of Histology and Embryology, Medical College, Shaoxing University, Zhejiang, China.
Institute of Neuroscience, Zhejiang University School of Medicine, Hangzhou, China.
Food Chem Toxicol. 2022 Jun;164:113091. doi: 10.1016/j.fct.2022.113091. Epub 2022 May 6.
Parkinson's disease is a common progressive neurodegenerative disease, and presently has no curative agent. Curcumin, as one of the natural polyphenols, has great potential in neurodegenerative diseases and other different pathological settings. The brain-derived neurotrophic factor (BDNF) and phosphatidylinositol 3 kinase (PI3k)/protein kinase B (Akt) signaling pathways are significantly involved nerve regeneration and anti-apoptotic activities. Currently, relevant studies have confirmed that curcumin has an optimistic impact on neuroprotection via regulating BDNF and PI3k/Akt signaling pathways in neurodegenerative disease. Here, we summarized the relationship between BDNF and PI3k/Akt signaling pathway, the main biological functions and neuroprotective effects of curcumin via activating BDNF and PI3k/Akt signaling pathways in Parkinson's disease. This paper illustrates that curcumin, as a neuroprotective agent, can delay the progression of Parkinson's disease by protecting nerve cells.
帕金森病是一种常见的进行性神经退行性疾病，目前尚无治愈方法。姜黄素作为一种天然多酚类物质，在神经退行性疾病和其他不同的病理状态下具有很大的潜力。脑源性神经营养因子（BDNF）和磷脂酰肌醇 3 激酶（PI3k）/蛋白激酶 B（Akt）信号通路在神经再生和抗细胞凋亡活性中起着重要作用。目前，相关研究证实，姜黄素通过调节神经退行性疾病中的 BDNF 和 PI3k/Akt 信号通路，对神经保护具有乐观的影响。在这里，我们总结了 BDNF 和 PI3k/Akt 信号通路之间的关系，以及姜黄素通过激活 BDNF 和 PI3k/Akt 信号通路在帕金森病中的主要生物学功能和神经保护作用。本文表明，姜黄素作为一种神经保护剂，可以通过保护神经细胞来延缓帕金森病的进展。
