Sivashanmugan Kundan, Albert Reece E, Lakowicz Joseph R
Center for Fluorescence Spectroscopy, Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, 655 W. Baltimore St, Baltimore, MD 21201, USA.
Department of Obstetrics, Gynecology and Reproductive Sciences, University of Maryland School of Medicine, 655 W. Baltimore St, Baltimore, MD 21201, USA.
Biosensors (Basel). 2025 Aug 14;15(8):532. doi: 10.3390/bios15080532.
Dehydration is a serious medical problem for elderly patients and young children. The most widely used diagnostics are measurements of sodium ion (Na) and potassium ion (K) in blood serum. Dehydration is difficult to diagnose even by trained health care professionals because the body compensates to maintain the appearance of skin. These measurements required a blood draw because specific tests are generally not available for only Na and K. The blood samples are analyzed by an electrolyte panel (EP) or a basic metabolic panel (BMP). Most hospitals limit EP and BMP to one per day to control costs. More frequent measurements of Na and K are needed, especially during rehydration. We designed a dehydration contact lens that can provide the Na and K concentrations as needed or for continuous monitoring. The measurements are obtained from the fluorescent lifetime or wavelength-ratiometric intensities of the Na- and K-sensitive fluorophores. The dehydration contact lens does not contain electronic components and are inexpensive to prepare.
脱水对于老年患者和幼儿来说是一个严重的医学问题。最广泛使用的诊断方法是测量血清中的钠离子（Na）和钾离子（K）。即使是训练有素的医护人员也很难诊断脱水，因为身体会进行代偿以维持皮肤外观。这些测量需要抽血，因为通常没有仅针对Na和K的特定检测方法。血样通过电解质检测板（EP）或基本代谢检测板（BMP）进行分析。大多数医院将EP和BMP的检测限制为每天一次以控制成本。需要更频繁地测量Na和K，尤其是在补液期间。我们设计了一种脱水隐形眼镜，它可以根据需要提供Na和K的浓度或进行连续监测。测量是通过Na和K敏感荧光团的荧光寿命或波长比率强度获得的。这种脱水隐形眼镜不包含电子元件，制备成本低廉。
