König R, Gutjahr P, Kruel R, Enders G, Spranger J
Helv Paediatr Acta. 1985 Dec;40(5):391-8.
Connatal varicella embryo-fetopathy is rare. A newborn is described with severe cutaneous lesions, contractures, and hypoplasia of limbs following maternal varicella at the 13th week of pregnancy. Persisting low CF- and ELISA IgG-antibodies up to the age of 18 months give evidence for a prenatal varicella infection. Varicella contact during pregnancy requires rapid serodiagnosis of the immune status; if the women are seronegative, the application of zoster-hyperimmunoglobulin is recommended.
先天性水痘胚胎病很罕见。本文描述了一名新生儿，其母亲在怀孕第13周感染水痘后，该新生儿出现严重皮肤病变、挛缩和肢体发育不全。直至18个月大时，CF和ELISA IgG抗体持续偏低，这证明存在产前水痘感染。孕期接触水痘需要快速进行免疫状态的血清学诊断；如果女性血清学阴性，建议应用带状疱疹高免疫球蛋白。
