Grijalva-Avila Julio Cesar, Villanueva-Fierro Ignacio, Martínez-Estrada Sandra Consuelo, Grijalva-Avila Gerardo, Gándara-Mireles Alonso, Rivera Gildardo, Loera-Castañeda Antonio, Almanza-Reyes Horacio, Patrón-Romero Leslie, Loera-Castañeda Verónica
Laboratorio de Farmacogenómica y Biomedicina Molecular, CIIDIR Unidad Durango, Instituto Politécnico Nacional, Durango 34220, Mexico.
Red Latinoamericana de Implementación y Validación de Guías Clínicas Farmacogenómicas (RELIVAF-CYTED), 28015 Madrid, Spain.
Metabolites. 2025 Aug 20;15(8):556. doi: 10.3390/metabo15080556.
Milk and dairy are rich in insulin-like growth factor 1 (IGF-1), a protein secreted through the action of growth hormone (GH) and implicated in growth and metabolism.
This study aimed to investigate the roles of milk intake and body composition and identify the presence of the single nucleotide variant (SNV) rs6214 in the insulin-like growth factor 1 gene () and its effects on the serum IGF-1 and GH levels and body composition.
We analyzed 110 volunteers with and without a history of milk intake. Through a case-control study with one hundred ten healthy volunteers, serum IGF-1 and GH levels were measured using the ELISA technique, the body composition was determined with bio-electrical impedance equipment, genotyping of the rs6214 SNV was carried out using real-time PCR, and a dietary questionnaire was administered to assess milk intake, with or without consumption.
The results showed that the highest levels of IGF-1 were found in people who regularly consumed milk, along with a lower body mass index (BMI) and percentage of fat. A lower BMI and fat percentage were associated with higher levels of IGF-1, lean mass, and SNV presence. Lower levels of BMI and percentages of subcutaneous and visceral fat were found in regular milk consumers.
Our study suggests that dairy intake and the IGF1 gene rs6214 SNV are associated with higher levels of IGF-1, high levels of lean mass, a low BMI, a low % fat, and low visceral fat.
牛奶和乳制品富含胰岛素样生长因子1（IGF-1），这是一种通过生长激素（GH）作用分泌的蛋白质，与生长和代谢有关。
本研究旨在调查牛奶摄入量与身体成分的作用关系，确定胰岛素样生长因子1基因（）中是否存在单核苷酸变异（SNV）rs6214，以及其对血清IGF-1、GH水平和身体成分的影响。
我们分析了110名有或无牛奶摄入史的志愿者。通过对110名健康志愿者进行病例对照研究，使用酶联免疫吸附测定（ELISA）技术测量血清IGF-1和GH水平，使用生物电阻抗设备测定身体成分，采用实时聚合酶链反应（PCR）对rs6214 SNV进行基因分型，并通过饮食问卷评估牛奶摄入量，无论是否饮用牛奶。
结果显示，经常饮用牛奶的人IGF-1水平最高，同时体重指数（BMI）和脂肪百分比更低。较低的BMI和脂肪百分比与较高的IGF-1水平、去脂体重和SNV存在相关。经常饮用牛奶的人BMI以及皮下和内脏脂肪百分比更低。
我们的研究表明，乳制品摄入和IGF1基因rs6214 SNV与较高的IGF-1水平、高去脂体重、低BMI、低脂肪百分比和低内脏脂肪有关。
