Fernández-Hernández Saray, Gil Javier, Sanjuán-Álvarez Marta, Sanz Ignacio, Herrero-Climent Mariano, Brizuela-Velasco Aritza
DENS-ia Research Group, Faculty of Health Sciences, Miguel de Cervantes European University, 47012 Valladolid, Spain.
Bioengineering Institute of Technology, Facultad de Medicina y Ciencias de la Salud, Universidad Internacional de Catalunya, C/Josep Trueta s/n, 08195 Sant Cugat del Vallès, Spain.
J Funct Biomater. 2025 Aug 1;16(8):283. doi: 10.3390/jfb16080283.
The thermo-chemical treatment of dental implants leads to the formation of sodium titanate crystals on their surface. When in contact with blood, these crystals dissolve and trigger an ionic exchange cascade, resulting in the formation of a calcium apatite layer. This study, carried out both in vitro and in an animal model, aimed to determine whether the cooling rate of the treatment affects the size of the deposited crystals, and whether this in turn influences wettability and early bone-to-implant contact (BIC). A total of 50 dental implants and 50 titanium discs were treated using four different cooling rates, along with a control group. Crystal size was analyzed on implant surfaces using scanning electron microscopy, and wettability was assessed on titanium discs using a goniometer. Finally, the implants were placed in the tibiae of 13 rabbits, and histological analysis was performed after three weeks to compare BIC among groups. Results suggest that a cooling rate of 75 °C/h produces smaller sodium titanate crystals, which are associated with significantly improved surface wettability and a higher percentage of bone-to-implant contact after 3 weeks of healing ( < 0.05).
牙种植体的热化学处理会使其表面形成钛酸钠晶体。当与血液接触时，这些晶体会溶解并引发离子交换级联反应，从而形成钙磷灰石层。本研究在体外和动物模型中进行，旨在确定处理的冷却速率是否会影响沉积晶体的大小，以及这是否反过来影响润湿性和早期骨与种植体的接触（BIC）。使用四种不同的冷却速率对总共50颗牙种植体和50个钛盘进行处理，并设置一个对照组。使用扫描电子显微镜分析种植体表面的晶体大小，使用测角仪评估钛盘的润湿性。最后，将种植体植入13只兔子的胫骨中，三周后进行组织学分析以比较各组之间的骨与种植体接触情况。结果表明，75℃/小时的冷却速率会产生较小的钛酸钠晶体，这与愈合3周后表面润湿性显著改善以及骨与种植体接触的百分比更高相关（<0.05）。
