Bai Ruqing, Chen Jiaqi, Zhang Ting, Chen Tao, Liu Xiaoying, Yang Weihu, Wong Tuck-Whye, Zhang Jianwei, Wang Li
State Key Laboratory of Mechanical Transmission for Advanced Equipment, Chongqing University, Chongqing 400044, China.
School of Big Health and Intelligent Engineering, School of Pharmacy, Chengdu Medical College, Chengdu 610500, China.
J Funct Biomater. 2025 Aug 15;16(8):294. doi: 10.3390/jfb16080294.
In this study, a shape-changeable 3D scaffold with photothermal effects was developed to address the clinical challenges of complex bone defects. The multifunctional construct was fabricated via in situ polymerization combined with a gas foaming technique, creating hierarchical porous architectures that mimic the native bone extracellular matrix. By incorporating polydopamine (PDA)-modified amorphous calcium phosphate (CA) into poly(propylene glycol) (PPG)- and poly(ԑ-caprolactone) (PCL)-based polyurethane (PU). The obtained scaffolds achieved osteoinductive potential for bone tissue engineering. The surface PDA modification of CA enabled efficient photothermal shape conversion under near-infrared (NIR) irradiation, facilitating non-invasive remote control of localized hyperthermia. The optimized scaffolds exhibited interconnected porosity (approximately 70%) with osteoconductive pore channels (200-500 μm), resulting in good osteoinduction in cell culture, and precise shape-memory recovery at physiological temperatures (~40 °C) under NIR for minimally invasive delivery. The synergistic effect of osteogenesis promotion and photothermal transition demonstrated this programmable scaffold as a promising solution for integrated minimally invasive bone repair and defect reconstruction.
在本研究中，开发了一种具有光热效应的可变形三维支架，以应对复杂骨缺损的临床挑战。该多功能构建体通过原位聚合结合气体发泡技术制备而成，形成了模仿天然骨细胞外基质的分级多孔结构。通过将聚多巴胺（PDA）修饰的无定形磷酸钙（CA）掺入基于聚丙二醇（PPG）和聚己内酯（PCL）的聚氨酯（PU）中。所获得的支架实现了骨组织工程的骨诱导潜力。CA的表面PDA修饰能够在近红外（NIR）照射下实现高效的光热形状转换，便于对局部热疗进行非侵入性远程控制。优化后的支架具有相互连通的孔隙率（约70%）和骨传导性孔隙通道（200 - 500μm），在细胞培养中具有良好的骨诱导能力，并且在生理温度（约40°C）下，在NIR照射下能实现精确的形状记忆恢复，以用于微创递送。促进骨生成和光热转变的协同效应表明，这种可编程支架是综合微创骨修复和缺损重建的一种有前景的解决方案。
