Lee Haeshin, Dellatore Shara M, Miller William M, Messersmith Phillip B
Biomedical Engineering, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208, USA.
Science. 2007 Oct 19;318(5849):426-30. doi: 10.1126/science.1147241.
We report a method to form multifunctional polymer coatings through simple dip-coating of objects in an aqueous solution of dopamine. Inspired by the composition of adhesive proteins in mussels, we used dopamine self-polymerization to form thin, surface-adherent polydopamine films onto a wide range of inorganic and organic materials, including noble metals, oxides, polymers, semiconductors, and ceramics. Secondary reactions can be used to create a variety of ad-layers, including self-assembled monolayers through deposition of long-chain molecular building blocks, metal films by electroless metallization, and bioinert and bioactive surfaces via grafting of macromolecules.
我们报道了一种通过将物体简单浸渍于多巴胺水溶液中来形成多功能聚合物涂层的方法。受贻贝中粘附蛋白组成的启发,我们利用多巴胺的自聚合作用,在包括贵金属、氧化物、聚合物、半导体和陶瓷在内的多种无机和有机材料表面形成薄的、附着于表面的聚多巴胺膜。二次反应可用于创建各种附加层,包括通过沉积长链分子构建块形成自组装单分子层、通过化学镀形成金属膜以及通过大分子接枝形成生物惰性和生物活性表面。