Buscemi Salvatore, Bonventre Giulia, Gottardo Andrea, Licciardi Mariano, Palumbo Fabio Salvatore, Cassata Giovanni, Cicero Luca, Lo Monte Giulia, Puleio Roberto, Lo Monte Attilio Ignazio
Di Cristina Benfratelli Hospital, Piazza Nicola Leotta 4, 90127 Palermo, Italy.
Department of Precision Medicine in Medical, Surgical and Critical Care Area (Me.Pre.C.C.), University of Palermo, Via Liborio Giuffrè 5, 90127 Palermo, Italy.
J Funct Biomater. 2025 Aug 18;16(8):297. doi: 10.3390/jfb16080297.
Common bile duct (CBD) treatments are often associated with complications, limiting long-term efficacy. To overcome these issues, polymeric grafts have been suggested as promising alternatives, since they are highly customizable, biocompatible, and may reduce side effects frequency. A systematic review was conducted, interrogating MEDLINE and Cochrane Library. Next, an in vivo study involved 20 pigs, which underwent a former controlled biliary injury. To repair the defect, a ()- ()- () scaffold was implanted. The animals were sacrificed at one and three months for gross and histological examinations, to assess tissue integration and healing outcomes. The systematic review highlighted that such scaffolds have shown promising results in CBD regeneration, both in single and joined applications. These findings were confirmed by the in vivo study, where the use of such scaffolds-particularly, the planar ones-led to safe and complete bile duct regeneration. Histological analysis revealed lymphomonocytic infiltrates and neovascularization, while microscopic examination showed progressive scaffold degradation accompanied by biliary tissue regeneration. Experimental results are consistent with the literature, confirming the potential of such polymeric scaffolds in aiding complete CBD regeneration and being reabsorbed shortly after. Still, further studies are needed to fully validate their translational application. : CRD420251115056.
胆总管（CBD）治疗常常伴有并发症，限制了长期疗效。为克服这些问题，聚合物移植物已被视为有前景的替代方案，因为它们具有高度可定制性、生物相容性，且可能降低副作用发生率。我们进行了一项系统综述，检索了MEDLINE和Cochrane图书馆。接下来，一项体内研究纳入了20头猪，这些猪先前经历了可控性胆管损伤。为修复缺损，植入了一个（）-（）-（）支架。在1个月和3个月时处死动物进行大体和组织学检查，以评估组织整合和愈合结果。系统综述强调，此类支架在胆总管再生的单次和联合应用中均显示出有前景的结果。体内研究证实了这些发现，其中使用此类支架——特别是平面支架——可实现安全且完全的胆管再生。组织学分析显示有淋巴细胞浸润和新生血管形成，而显微镜检查显示支架逐渐降解并伴有胆管组织再生。实验结果与文献一致，证实了此类聚合物支架在促进胆总管完全再生并在短期内被吸收方面的潜力。不过，仍需进一步研究以充分验证其转化应用。：CRD420251115056
