Christodoulou Stylianos, Herodotou Fedonas, Quattrocchi Annalisa, Potamitis Theodoros, Choleva Vivi
Ophthalmology Department Makarios Hospital, Nicosia 2011, Cyprus.
Medical School, University of Cyprus, Nicosia 2029, Cyprus.
J Pers Med. 2025 Aug 19;15(8):388. doi: 10.3390/jpm15080388.
: We aimed to investigate the incidence, treatment patterns, and associated risk factors of type 1 retinopathy of prematurity (ROP) in the only tertiary-level Neonatal Intensive Care Unit (NICU) in Cyprus. : This retrospective study included all infants screened for ROP between January and December 2023. Data were collected from standardized NICU discharge summaries and included gestational age (GA), birth weight (BW), multiple birth, systemic infection, blood transfusion, oxygen therapy, surgical interventions, and ROP outcomes. Infants were categorized into non-ROP, non-type 1 ROP, and type 1 ROP groups. Statistical analysis was performed to identify differences in risk factor distribution. : Among 183 infants, 33 (18.0%) developed ROP, with 11 (6.0%) requiring treatment for type 1 ROP. All infants with type 1 ROP were born at ≤28 weeks GA and weighed <1501 g. Type 1 ROP was significantly associated with lower GA, lower BW, systemic infection, surgery, and prolonged oxygen support ( < 0.05). Six infants were treated with laser and three with intravitreal bevacizumab. No recurrence was observed in the anti-VEGF group during 18 months of follow-up. Two infants with aggressive ROP died before treatment. : Type 1 ROP in Cyprus occurred exclusively in extremely preterm infants, associated with the cumulative effect of multiple risk factors. Laser remained the primary treatment, while anti-VEGF was used selectively with favorable outcomes. This study emphasizes the importance of tailoring ROP screening and treatment strategies based on individual neonatal risk profiles, supporting a personalized approach to neonatal ophthalmic care.
我们旨在调查塞浦路斯唯一的三级新生儿重症监护病房（NICU）中1型早产儿视网膜病变（ROP）的发病率、治疗模式及相关危险因素。
这项回顾性研究纳入了2023年1月至12月期间所有接受ROP筛查的婴儿。数据从标准化的NICU出院总结中收集，包括胎龄（GA）、出生体重（BW）、多胎妊娠、全身感染、输血、氧疗、手术干预及ROP结局。婴儿被分为非ROP组、非1型ROP组和1型ROP组。进行统计分析以确定危险因素分布的差异。
在183名婴儿中，33名（18.0%）发生了ROP，其中11名（6.0%）因1型ROP需要治疗。所有1型ROP婴儿的胎龄均≤28周，体重<1501g。1型ROP与较低的胎龄、较低的出生体重、全身感染、手术及长时间氧疗显著相关（P<0.05）。6名婴儿接受了激光治疗，3名接受了玻璃体腔内注射贝伐单抗治疗。在18个月的随访中，抗VEGF组未观察到复发。2名患有侵袭性ROP的婴儿在治疗前死亡。
塞浦路斯的1型ROP仅发生于极早产儿，与多种危险因素的累积效应有关。激光仍然是主要治疗方法，而抗VEGF则选择性使用，效果良好。本研究强调了根据个体新生儿风险特征定制ROP筛查和治疗策略的重要性，支持采用个性化的新生儿眼科护理方法。
