Uhlinger C, Johnstone C
J Am Vet Med Assoc. 1985 Dec 15;187(12):1362-6.
A survey was conducted to determine the prevalence of benzimidazole (BZ)-resistant small strongyles in horses in a southeastern Pennsylvania practice. Resistant parasites were found in 291 of 342 horses surveyed. Anthelmintic practices and pasture management factors in use for 3 to 6 years did not correlate with the presence of resistant small strongyles. Benzimidazole-resistant small strongyles were recovered in horses that had been treated alternately with BZ and non-BZ products and in horses receiving BZ products as infrequently as twice a year. However, inasmuch as the horses may have been infected with resistant small strongyles before the various anthelmintic schedules were implemented, it was not possible to attribute BZ-resistance to any particular pattern of drug use. Fifty-one (14.9%) horses had BZ-susceptible small strongyles: these horses were on poor overall parasite control programs and had received BZ products no more than once a year. Benzimidazole-piperazine and non-BZ drugs were effective in herds infected with BZ-resistant small strongyles.
在宾夕法尼亚州东南部的一家诊所进行了一项调查,以确定马体内对苯并咪唑(BZ)耐药的小型圆线虫的流行情况。在接受调查的342匹马中,有291匹马发现了耐药寄生虫。使用3至6年的驱虫措施和牧场管理因素与耐药小型圆线虫的存在无关。在交替使用BZ和非BZ产品治疗的马匹以及每年仅接受两次BZ产品治疗的马匹中,均发现了对苯并咪唑耐药的小型圆线虫。然而,由于这些马匹在实施各种驱虫计划之前可能已经感染了耐药小型圆线虫,因此无法将BZ耐药性归因于任何特定的用药模式。51匹(14.9%)马体内的小型圆线虫对BZ敏感:这些马的总体寄生虫控制方案较差,每年接受BZ产品治疗不超过一次。苯并咪唑-哌嗪和非BZ药物对感染了对BZ耐药的小型圆线虫的马群有效。