Geng Yingxue, Zhao Qun, Wang Junfeng, Cao Yan, Wang Yunshan, Gou Wenshi, Zhang Linfeng, Tian Senlin
Faculty of Civil and Hydraulic Engineering, Xichang University, Xichang 615013, China.
Faculty of Environmental Science and Engineering, Kunming University of Science and Technology, Kunming 650500, China.
Nanomaterials (Basel). 2025 Aug 14;15(16):1244. doi: 10.3390/nano15161244.
The interaction between carbon nanoparticles (CNs) and Langmuir monolayers of 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) as a model pulmonary surfactant (PS) film was studied to shed light on the physicochemical bases underlying the potential adverse effects associated with pollutant inhalation. The results indicated that the surface pressure-area isotherms of the DPPC monolayers shifted toward lower molecular areas, and the compression modulus was reduced in the presence of CNs, hindering the ability of the DPPC monolayers to reduce the surface tension. The relaxation process of the DPPC monolayers were influenced, and the surface morphology and the continuity of the monolayers were destroyed by the penetration of CNs into the DPPC monolayers. The molecular dynamics simulation revealed that particle incorporation into the DPPC monolayers reduced the packing density of the DPPC molecules, worsening the mechanical performance of the monolayers. This effect was attributed to the strong binding trend between the CNs and the DPPC molecules. These results demonstrated that CNs could alter the relaxation mechanisms of the PS film, and this may cause a modification of the inhaled particle transport at the PS film and contribute to adverse health effects in the respiratory system of workers involved in the CN production process.
研究了碳纳米颗粒（CNs）与作为模型肺表面活性剂（PS）膜的1,2-二棕榈酰-sn-甘油-3-磷酸胆碱（DPPC）的Langmuir单层之间的相互作用，以阐明与污染物吸入相关的潜在不利影响的物理化学基础。结果表明，在存在CNs的情况下，DPPC单层的表面压力-面积等温线向较低分子面积移动，压缩模量降低，阻碍了DPPC单层降低表面张力的能力。DPPC单层的松弛过程受到影响，并且由于CNs渗透到DPPC单层中，单层的表面形态和连续性被破坏。分子动力学模拟表明，颗粒掺入DPPC单层中降低了DPPC分子的堆积密度，使单层的机械性能变差。这种效应归因于CNs与DPPC分子之间的强烈结合趋势。这些结果表明，CNs可以改变PS膜的松弛机制，这可能会导致PS膜处吸入颗粒传输的改变，并对参与CN生产过程的工人的呼吸系统产生不利健康影响。
