Wu Yan, Li Qianjin, Deng Rendi, Wang Rui, Fu Junfen, Ren Fangfang, Jin Hangbiao
Department of Endocrinology, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou 310014, China.
Department of Endocrinology and Metabolic Diseases, Zhejiang Greentown Cardiovascular Hospital, Hangzhou 310014, China.
Toxics. 2025 Aug 7;13(8):664. doi: 10.3390/toxics13080664.
A series of 6:2 fluorotelomer ethoxylates (FTEOs) has been recently detected in human serum. Whether it has the potential to disrupt lipid metabolism in human populations remains largely unexplored. This study quantified serum concentrations of 6:2 FTEOs in 237 healthy Chinese adults, examined the gender- and age-specific differences in serum levels of 6:2 FTEOs, and investigated the associations between serum levels of 6:2 FTEOs and lipid profiles for the first time. Nine 6:2 FTEO homologues were detected in collected human serum, with detection frequencies of 22-81%. 6:2 FTEO8 and 6:2 FTEO9 were the more abundant 6:2 FTEO homologues in human serum, displaying the mean levels of 0.69 ng/mL (range < LOD-7.36 ng/mL) and 0.71 ng/mL (<LOD-8.12 ng/mL), respectively. Male participants had much higher ( < 0.05) mean serum levels of 6:2 FTEO6 (0.61 vs. 0.31 ng/mL), 6:2 FTEO7 (0.44 vs. 0.21 ng/mL), 6:2 FTEO8 (0.91 vs. 0.38 ng/mL), and 6:2 FTEO11 (0.35 vs. 0.18 ng/mL) than female subjects. Correlation analysis revealed a significantly positive relationship ( < 0.01) between the age of participants and human serum concentrations of 6:2 FTEO6-6:2 FTEO11. Multivariate linear regression identified significant positive associations between specific 6:2 FTEO homologues (e.g., 6:2 FTEO6, 6:2 FTEO8-6:2 FTEO10) and elevated total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and triglyceride levels.
最近在人体血清中检测到一系列6:2氟调聚物乙氧基化物（FTEO）。其是否有扰乱人群脂质代谢的潜力在很大程度上仍未得到探索。本研究对237名健康中国成年人血清中6:2 FTEO的浓度进行了量化，研究了6:2 FTEO血清水平的性别和年龄差异，并首次调查了6:2 FTEO血清水平与血脂谱之间的关联。在收集的人体血清中检测到9种6:2 FTEO同系物，检测频率为22%-81%。6:2 FTEO8和6:2 FTEO9是人体血清中含量较高的6:2 FTEO同系物，平均水平分别为0.69 ng/mL（范围<检测限-7.36 ng/mL）和0.71 ng/mL（<检测限-8.12 ng/mL）。男性参与者血清中6:2 FTEO6（0.61对0.31 ng/mL）、6:2 FTEO7（0.44对0.21 ng/mL）、6:2 FTEO8（0.91对0.38 ng/mL）和6:2 FTEO11（0.35对0.18 ng/mL）的平均水平显著高于女性受试者（<0.05）。相关性分析显示，参与者年龄与人体血清中6:2 FTEO6至6:2 FTEO11的浓度之间存在显著正相关（<0.01）。多变量线性回归确定特定的6:2 FTEO同系物（如6:2 FTEO6、6:2 FTEO8至6:2 FTEO10）与总胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇和甘油三酯水平升高之间存在显著正相关。
