Papakonstantinou Georgios I, Eliopoulos Christos, Meletis Eleftherios, Riahi Insaf, Stampinas Evangelos-Georgios, Arapoglou Dimitrios, Gougoulis Dimitrios, Dimoveli Konstantina, Filippou Dimitrios, Manouras Alexandros, Tsekouras Nikolaos, Fotos Lampros, Kostoulas Polychronis, Christodoulopoulos Georgios, Papatsiros Vasileios G
Clinic of Medicine, Faculty of Veterinary Medicine, University of Thessaly, 43100 Karditsa, Greece.
Institute of Technology of Agricultural Products, Hellenic Agricultural Organization-Demeter (HAO-Demeter), 14123 Athens, Greece.
Toxins (Basel). 2025 Aug 21;17(8):425. doi: 10.3390/toxins17080425.
Mycotoxins are common feed contaminants that can affect the health, immune function, and productivity of ruminants by causing oxidative stress and organ dysfunction. In this field study, the effects of a phytogenic multicomponent mycotoxin detoxifier on oxidative status, liver function, udder health, and productive parameters were investigated in dairy ewes. One hundred clinically healthy ewes were randomly assigned to either a control group or a treatment group, with the latter receiving 1.5 kg/ton of the detoxifier over a 90-day period during lactation. The detoxifying agent contained adsorptive clays as well as phytogenic ingredients such as silymarin and curcumin, which are known for their hepatoprotective and antioxidant properties. Blood, milk, and colostrum samples were collected and analyzed for oxidative stress markers (TBARS and protein carbonyl (CARBS)), total antioxidant capacity (TAC), liver enzymes (ALT, AST, and ALP), and milk quality parameters (fat, protein, and solid content). Clinical assessments included mastitis scoring, udder inflammation, and fecal consistency. The treated ewes showed a statistically significant reduction in blood plasma and milk oxidative stress markers and liver enzyme levels while at the same time improving the fat and solid content of the milk. The incidence and severity of mastitis, udder reddening, and lactation abnormalities were lower in the treatment group. Brix refractometry indicated improved colostrum quality in the treated ewes. These results suggest that the detoxifier improved the oxidative balance, liver function, and overall health and productivity of dairy ewes under field conditions, supporting its use as a practical nutritional measure.
霉菌毒素是常见的饲料污染物，可通过引起氧化应激和器官功能障碍影响反刍动物的健康、免疫功能和生产力。在这项实地研究中，研究了一种植物源多组分霉菌毒素解毒剂对泌乳期母羊氧化状态、肝功能、乳房健康和生产性能参数的影响。100只临床健康的母羊被随机分为对照组或治疗组，后者在泌乳期的90天内每天每顿接受1.5千克解毒剂。解毒剂含有吸附性粘土以及水飞蓟宾和姜黄素等植物成分，这些成分以其肝脏保护和抗氧化特性而闻名。采集血液、牛奶和初乳样本，分析氧化应激标志物（硫代巴比妥酸反应物和蛋白质羰基）、总抗氧化能力、肝酶（谷丙转氨酶、谷草转氨酶和碱性磷酸酶）以及牛奶质量参数（脂肪、蛋白质和固体含量）。临床评估包括乳腺炎评分、乳房炎症和粪便稠度。治疗组母羊血浆和牛奶中的氧化应激标志物及肝酶水平在统计学上显著降低，同时牛奶的脂肪和固体含量有所提高。治疗组乳腺炎、乳房发红和泌乳异常的发生率及严重程度较低。糖度折射测定法表明治疗组母羊的初乳质量有所改善。这些结果表明，在实地条件下，解毒剂改善了母羊的氧化平衡、肝功能以及整体健康和生产力，支持将其用作一种实用的营养措施。
