Silnutzer J E, Barnes D W
In Vitro Cell Dev Biol. 1985 Jan;21(1):73-8. doi: 10.1007/BF02620918.
Four synthetic peptides related in amino acid sequence to the area of the fibronectin molecule thought to be involved in cell binding were tested for the ability to inhibit cell spreading promoted by several different attachment factors. Effects of the peptides were assayed on a number of cell types. For all cell types tested, peptides effective at inhibiting fibronectin-promoted cell spreading were found also to inhibit cell spreading promoted by human serum spreading factor (SF). These peptides were also capable of inhibiting to a lesser extent cell spreading promoted by other attachment factors, although this phenomenon was dependent on the cell type examined.
测试了四种在氨基酸序列上与纤连蛋白分子中被认为参与细胞黏附的区域相关的合成肽，以检测它们抑制由几种不同黏附因子促进的细胞铺展的能力。在多种细胞类型上测定了这些肽的作用。对于所有测试的细胞类型，发现能有效抑制纤连蛋白促进的细胞铺展的肽也能抑制人血清铺展因子（SF）促进的细胞铺展。这些肽在较小程度上也能够抑制由其他黏附因子促进的细胞铺展，不过这种现象取决于所检测的细胞类型。
