Fu Ruxing, Meng Dong, Han Xiao, Liu Lu, Chen Chichia, Zheng Ran, Zhao Yepin, Zhang Xuexiang, Lin Xiao, Hasani Mahdi, Song Yang, Liang Tingxizi, Wen Di, Li Hongjun, Yavuz Ilhan, Feng Huiheng, Gu Zhen, Li Zhenxing, Li Song, Liu Feng, Yang Yang
Department of Materials Science and Engineering, University of California, Los Angeles, CA 90095, USA.
Department of Bioengineering, University of California, Los Angeles, CA 90095, USA.
Sci Adv. 2025 Aug 29;11(35):eadp2757. doi: 10.1126/sciadv.adp2757. Epub 2025 Aug 27.
Photoactivated drug delivery is a promising therapeutic strategy that enables spatial and temporal control of payload release. A critical component of this approach is the photoresponsive material that has sufficient drug-loading capacity and can be actuated by near-infrared (NIR) light with considerable penetration depths. Here, we establish a photoactivated drug delivery platform based on the π-stacked organic framework (πOF), which demonstrates an intrinsic NIR absorption and superior photothermal effect. πOF not only has considerable loading capacity for a variety of drugs but also prompts the inducible burst release of loaded cargoes under NIR irradiation with notable increase of the release rate. Based on these features, πOF is used to effectively modulate the delivery of resiquimod (R848) and simultaneously induce photothermal effect by NIR irradiation. In 4T1-bearing mouse models, the photoactivated release of R848 can significantly potentiate treatment efficacy.
光激活药物递送是一种很有前景的治疗策略，能够实现药物释放的时空控制。这种方法的一个关键组成部分是具有足够载药能力且能被具有相当穿透深度的近红外（NIR）光激活的光响应材料。在此，我们基于π堆积有机框架（πOF）建立了一个光激活药物递送平台，该平台表现出固有的近红外吸收和优异的光热效应。πOF不仅对多种药物具有可观的载药能力，而且在近红外照射下能促使负载货物诱导性突发释放，释放速率显著增加。基于这些特性，πOF被用于有效调节瑞喹莫德（R848）的递送，并同时通过近红外照射诱导光热效应。在携带4T1的小鼠模型中，R848的光激活释放可显著增强治疗效果。
