Górna Ilona, Kowalówka Magdalena, Więckowska Barbara, Banaszak Michalina, Kosewski Grzegorz, Grządzielska Olivia, Przysławski Juliusz, Drzymała-Czyż Sławomira
Department of Bromatology, Poznan University of Medical Sciences, 3 Rokietnicka St., 60-806 Poznan, Poland.
Department of Computer Science and Statistics, Poznan University of Medical Science, 7 Rokietnicka St., 60-806 Poznan, Poland.
Curr Issues Mol Biol. 2025 Aug 2;47(8):611. doi: 10.3390/cimb47080611.
Oxidative stress is a key factor in the pathogenesis of many chronic diseases, especially in postmenopausal women. Xylitol, a sugar alcohol with potential antioxidant properties, may affect oxidative balance when used as a sugar substitute.
This pilot study aimed to assess the effect of replacing sucrose with xylitol on serum antioxidant capacity in postmenopausal women.
This study included 34 women aged 50 to 65 years who successively consumed 5 g/d, 10 g/d, and 15 g/d of xylitol. The dietary intervention lasted a total of 6 weeks, with each phase covering a 2-week period. Diet was assessed twice based on a 7-day dietary interview (Diet 6.0, NIZP-PZH, Warsaw). The material for this study was venous blood. Antioxidant capacity was determined using the DPPH radical scavenging method and the ABTS cation radical scavenging method.
In both methods, a significant increase in serum antioxidant potential was observed after replacing sugar with xylitol ( < 0.0001). An increase in the ability to neutralize free radicals was observed in almost all women studied. Additional analysis of the effect of selected nutrients on the obtained effects of the nutritional intervention showed that the most significant effect could potentially be exerted by manganese, maltose, sucrose, and mercury, and the strongest positive correlation was exerted by vitamin A, retinol, and vitamin E. Although the values obtained in the constructed models were not statistically significant, the large effect indicates potentially significant relationships that could have a significant impact on serum antioxidant potential in the studied group of women.
The results suggest a potential role of xylitol in enhancing antioxidant defense mechanisms in menopausal women. Although the sample size was relatively small, this study was powered at approximately 80% to detect large effects, supporting the reliability of the observed results. Nevertheless, given the pilot nature of this study, further research with larger cohorts is warranted to confirm these preliminary observations and to clarify the clinical significance of xylitol supplementation in populations exposed to oxidative stress.
氧化应激是许多慢性疾病发病机制中的关键因素，在绝经后女性中尤为如此。木糖醇是一种具有潜在抗氧化特性的糖醇，用作糖替代品时可能会影响氧化平衡。
这项初步研究旨在评估用木糖醇替代蔗糖对绝经后女性血清抗氧化能力的影响。
本研究纳入了34名年龄在50至65岁之间的女性，她们依次摄入5克/天、10克/天和15克/天的木糖醇。饮食干预共持续6周，每个阶段为期2周。根据7天饮食访谈（Diet 6.0，华沙NIZP - PZH）对饮食进行两次评估。本研究的材料为静脉血。使用DPPH自由基清除法和ABTS阳离子自由基清除法测定抗氧化能力。
在两种方法中，用木糖醇替代糖后，血清抗氧化潜力均显著增加（<0.0001）。几乎所有研究的女性中都观察到自由基中和能力的增强。对选定营养素对营养干预所得效果的影响进行的额外分析表明，锰、麦芽糖、蔗糖和汞可能发挥最显著的作用，而维生素A、视黄醇和维生素E呈现最强的正相关。尽管构建模型中获得的值无统计学意义，但较大的效应表明可能存在显著关系，这可能对所研究女性群体的血清抗氧化潜力产生重大影响。
结果表明木糖醇在增强绝经后女性抗氧化防御机制方面具有潜在作用。尽管样本量相对较小，但本研究有大约80%的把握度检测到较大效应，支持了观察结果的可靠性。然而，鉴于本研究的初步性质，有必要进行更大样本量的进一步研究，以证实这些初步观察结果，并阐明木糖醇补充剂在遭受氧化应激人群中的临床意义。
