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利奈唑胺和美罗培南治疗印度耳诺卡菌性足菌肿

Linezolid and Meropenem for Nocardia otitidiscaviarum Actinomycetoma, India.

作者信息

Sardana Kabir, Sharath Savitha, Sachdeva Soumya, Das Shukla, Rai Gargi, Singh Praveen Kumar

出版信息

Emerg Infect Dis. 2025 Sep;31(9):1863-1865. doi: 10.3201/eid3109.250514.

DOI:10.3201/eid3109.250514
PMID:40867086
Abstract

Treatment of actinomycotic mycetoma with joint involvement is challenging. We present a patient in India with actinomycotic mycetoma who reached complete cure and remission after linezolid and meropenem treatment with a 2-year posttreatment follow-up. Clinicians should use novel drug regimens based on subspecies variations of Nocardia and regional drug susceptibility patterns to guide therapy.

摘要

治疗合并关节受累的放线菌性足菌肿具有挑战性。我们报告了一名印度的放线菌性足菌肿患者,在接受利奈唑胺和美罗培南治疗后实现了完全治愈和缓解,并进行了为期2年的治疗后随访。临床医生应根据诺卡菌的亚种变异和区域药敏模式采用新的药物方案来指导治疗。

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本文引用的文献

1
A fatal case of disseminated nocardiosis due to Nocardia otitidiscaviarum resistant to trimethoprim-sulfamethoxazole: case report and literature review.因对甲氧苄啶-磺胺甲噁唑耐药的耳炎奴卡菌导致的播散性奴卡菌病 1 例:病例报告及文献复习。
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Epidemiology and Antimicrobial Resistance Profiles of the Species in China, 2009 to 2021.2009 年至 2021 年中国 种的流行病学和抗菌药物耐药谱。
Microbiol Spectr. 2022 Apr 27;10(2):e0156021. doi: 10.1128/spectrum.01560-21. Epub 2022 Mar 2.
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A combination of trimethoprim/sulfamethoxazole with linezolid is useful for actinomycotic mycetoma: A summary of the existing data and the rationale of combination therapy.
Indian J Dermatol Venereol Leprol. 2022 Mar-Apr;88(2):212-213. doi: 10.25259/IJDVL_539_2021.
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Newer therapeutic modalities for Actinomycetoma by Nocardia species.
Int J Dermatol. 2018 Sep;57(9):e64-e65. doi: 10.1111/ijd.14073. Epub 2018 Jun 19.
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Mycetoma: reviewing a neglected disease.放线菌病:回顾一种被忽视的疾病。
Clin Exp Dermatol. 2019 Mar;44(2):123-129. doi: 10.1111/ced.13642. Epub 2018 May 28.
6
Mycetomas: an epidemiological, etiological, clinical, laboratory and therapeutic review.足菌肿:一项流行病学、病因学、临床、实验室及治疗综述
An Bras Dermatol. 2018 Jan-Feb;93(1):8-18. doi: 10.1590/abd1806-4841.20187075.
7
Susceptibility profiles of Nocardia spp. to antimicrobial and antituberculotic agents detected by a microplate Alamar Blue assay.奴卡菌属对抗菌药物和抗结核药物敏感性的微量 Alamar Blue 检测分析。
Sci Rep. 2017 Mar 2;7:43660. doi: 10.1038/srep43660.
8
Successful treatment of Nocardia actinomycetoma with meropenem and amikacin combination therapy.美罗培南和阿米卡星联合治疗诺卡氏放线菌病获得成功。
Int J Dermatol. 2011 Apr;50(4):443-5. doi: 10.1111/j.1365-4632.2010.04748.x.
9
Efficacy of imipenem therapy for Nocardia actinomycetomas refractory to sulfonamides.亚胺培南治疗磺胺类药物治疗无效的放线菌性 actinomycetomas 的疗效。
J Am Acad Dermatol. 2010 Feb;62(2):239-46. doi: 10.1016/j.jaad.2009.06.043. Epub 2009 Dec 11.
10
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J Antimicrob Chemother. 2009 Jul;64(1):73-8. doi: 10.1093/jac/dkp144. Epub 2009 Apr 27.