Boccali Elisa, Simonelli Carla, Salvi Beatrice, Paneroni Mara, Vitacca Michele, Di Pietro Davide Antonio
Istituti Clinici Scientifici Maugeri IRCCS, Neurorehabilitation of the Institute of Lumezzane, 25065 Lumezzane, Italy.
Istituti Clinici Scientifici Maugeri IRCCS, Cardiac Rehabilitation of the Institute of Lumezzane, 25065 Lumezzane, Italy.
Brain Sci. 2025 Jul 24;15(8):788. doi: 10.3390/brainsci15080788.
: Parkinson's disease (PD) is a neurodegenerative disorder that impairs mobility. is a common rehabilitation strategy for improving gait parameters in individuals with PD. This systematic review evaluated the effectiveness of TT in improving motor function, walking ability, and overall functional mobility in PD patients. : We compared TT to other forms of gait and motor rehabilitation, including conventional and robotic gait training. Trials that compared a treadmill training group with a non-intervention group were excluded from this review. We searched multiple databases for RCTs involving Parkinson's patients until January 2025. The primary outcomes were motor function (UPDRS-III) and walking ability (6 MWT and TUG test). We identified 285 articles; 199 were excluded after screening. We assessed the full text of 86 articles for eligibility, and 13 RCTs met the inclusion criteria. Some of them were included in the meta-analysis. The TT group showed a significant improvement in UPDRS-III scores [mean difference (MD): -1.36 (95% CI: -2.60 to -0.11)] and greater improvement in TUG performance [MD, -1.75 (95% CI: -2.69 to -0.81)]. No significant difference in walking capacity as assessed through the 6 MWT was observed [MD: 26.03 (95% CI: -6.72 to 58.77). The current study suggests that TT is effective in improving the motor symptoms and functional mobility associated with PD. Further studies are needed to develop protocols that consider the patients' clinical characteristics, disease stage, exercise tolerance, and respiratory function.
帕金森病（PD）是一种损害运动能力的神经退行性疾病。 是改善帕金森病患者步态参数的常见康复策略。本系统评价评估了跑步机训练（TT）对改善帕金森病患者运动功能、步行能力和整体功能活动能力的有效性。 ：我们将TT与其他形式的步态和运动康复进行了比较，包括传统的和机器人辅助的步态训练。将比较跑步机训练组与非干预组的试验排除在本评价之外。我们在多个数据库中检索了截至2025年1月涉及帕金森病患者的随机对照试验（RCT）。主要结局指标为运动功能（统一帕金森病评定量表第三部分，UPDRS-III）和步行能力（6分钟步行试验，6 MWT和起立-行走试验，TUG试验）。 我们共识别出285篇文章；筛选后排除199篇。我们评估了86篇文章的全文以确定其是否符合纳入标准，13项RCT符合纳入标准。其中一些被纳入荟萃分析。TT组在UPDRS-III评分上有显著改善[平均差（MD）：-1.36（95%可信区间：-2.60至-0.11）]，在TUG表现上有更大改善[MD，-1.75（95%可信区间：-2.69至-0.81）]。通过6 MWT评估的步行能力没有观察到显著差异[MD：26.03（95%可信区间：-6.72至58.77）。 当前研究表明，TT在改善与帕金森病相关的运动症状和功能活动能力方面是有效的。需要进一步开展研究以制定考虑患者临床特征、疾病阶段、运动耐量和呼吸功能的方案。
