抗氧化基因中的遗传变异调节墨西哥儿童肥胖相关氧化应激标志物之间的关系。

Genetic Variants in Antioxidant Genes Modulate the Relationships Among Obesity-Related Oxidative Stress Markers in Mexican Children.

作者信息

Nava-Cabrera Ana, Ramírez-Cruz Armando, Gómez-Zamudio Jaime, Pérez-Bautista Araceli, Ruiz-Queb Linda Esther, Vazquez-Moreno Miguel, Cruz Miguel

机构信息

Unidad de Investigación Médica en Bioquímica, Hospital de Especialidades, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Av. Cuauhtémoc 330, Col. Doctores, Delegación Cuauhtémoc, Mexico City C.P. 06720, Mexico.

Programa de Doctorado en Ciencias Médicas, Odontológicas y de la Salud, Universidad Nacional Autónoma de México, Mexico City C.P. 04510, Mexico.

出版信息

Antioxidants (Basel). 2025 Jul 22;14(8):896. doi: 10.3390/antiox14080896.

DOI:10.3390/antiox14080896

PMID:40867795

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12382951/

Abstract

Single-nucleotide polymorphisms (SNPs) in antioxidant genes could influence redox regulation from early life. We aimed to assess the direct and modulatory effects of SNPs in antioxidant genes ( rs4880, rs1050450, rs835337, rs1001179) on the relationships among obesity-related oxidative stress markers in Mexican children. Anthropometric data of 2946 unrelated children were analyzed in this cross-sectional study. SNPs were genotyped using TaqMan assay. Serum total antioxidant capacity (sTAC) and oxidative stress markers (thiobarbituric acid reactive substances [TBARS, as lipid peroxidation], and protein carbonyl [PC]) were assessed. Although no SNPs were associated with obesity ( ≥ 0.125), both sTAC ( = 0.001) and TBARS ( = 0.015) were positively associated with it. A negative relationship was also observed between sTAC and TBARS ( < 0.001). rs4880 was negatively associated with TBARS, while rs1050450 was inversely associated with both TBARS and PC levels ( ≤ 0.036). The inverse association between sTAC and TBARS remained significant only in non-carriers of rs4880 ( = 0.003) and rs1050450 ( = 0.002). Our data evidence that sTAC and TBARS are associated with obesity, showing a negative relationship in Mexican children who are non-carriers of rs4880 and rs1050450.

摘要

抗氧化基因中的单核苷酸多态性（SNP）可能从生命早期就影响氧化还原调节。我们旨在评估抗氧化基因（rs4880、rs1050450、rs835337、rs1001179）中的SNP对墨西哥儿童肥胖相关氧化应激标志物之间关系的直接和调节作用。在这项横断面研究中分析了2946名无亲缘关系儿童的人体测量数据。使用TaqMan分析法对SNP进行基因分型。评估了血清总抗氧化能力（sTAC）和氧化应激标志物（硫代巴比妥酸反应性物质[TBARS，作为脂质过氧化]和蛋白质羰基[PC]）。尽管没有SNP与肥胖相关（≥0.125），但sTAC（=0.001）和TBARS（=0.015）均与肥胖呈正相关。还观察到sTAC和TBARS之间存在负相关（<0.001）。rs4880与TBARS呈负相关，而rs1050450与TBARS和PC水平均呈负相关（≤0.036）。sTAC和TBARS之间的负相关仅在rs4880（=0.003）和rs1050450（=0.002）的非携带者中仍然显著。我们的数据证明，sTAC和TBARS与肥胖相关，在rs4880和rs1050450的非携带者墨西哥儿童中呈负相关。