Rupérez Azahara I, Mesa María D, Anguita-Ruiz Augusto, González-Gil Esther M, Vázquez-Cobela Rocío, Moreno Luis A, Gil Ángel, Gil-Campos Mercedes, Leis Rosaura, Bueno Gloria, Aguilera Concepción M
GENUD Research Group, Instituto Agroalimentario de Aragón (IA2), Instituto de Investigación Sanitaria (IIS) Aragón, University of Zaragoza, 50013 Zaragoza, Spain.
Department of Biochemistry and Molecular Biology II, Institute of Nutrition and Food Technology "José Mataix", Center of Biomedical Research, University of Granada, Armilla, 18016 Granada, Spain.
Antioxidants (Basel). 2020 Jul 15;9(7):618. doi: 10.3390/antiox9070618.
Oxidative stress could help explain the relationship between childhood obesity and a metabolically unhealthy (MU) status. Moreover, puberty could also influence this relationship, since it entails physiological cardiometabolic changes. We aimed to evaluate plasma antioxidants and oxidative stress biomarkers in MU and metabolically healthy (MH) prepubertal and pubertal children and their associations with pro-inflammatory and endothelial damage biomarkers, taking puberty into account. A total of 1444 Spanish children aged 3-17 years (48.9% males, 66% prepubertal, 47.1% with obesity) were recruited. Blood pressure, anthropometric and biochemical parameters were measured, and children were categorized as having a MU or MH status according to risk factors. Retinol, carotenes, tocopherols, total antioxidant capacity (TAC), oxidized low-density lipoprotein and selected pro-inflammatory and endothelial damage biomarkers were analyzed. General linear models adjusted for age, sex, recruitment center and body mass index, partial correlations and stepwise linear regressions were performed. Lower carotenes and tocopherols levels were found in MU than in MH children. Plasma TAC was lower in prepubertal and higher in pubertal children with obesity compared to normal-weight children. Antioxidants and oxidative stress biomarkers showed novel associations with several pro-inflammatory and endothelial damage biomarkers, with pubertal differences, supporting the importance of considering both the antioxidant and oxidative stress status and puberty in the prevention of metabolic diseases in childhood.
氧化应激有助于解释儿童肥胖与代谢不健康（MU）状态之间的关系。此外，青春期也可能影响这种关系，因为它会带来生理上的心脏代谢变化。我们旨在评估MU和代谢健康（MH）的青春期前和青春期儿童的血浆抗氧化剂和氧化应激生物标志物，以及它们与促炎和内皮损伤生物标志物的关联，并考虑青春期因素。共招募了1444名3至17岁的西班牙儿童（48.9%为男性，66%为青春期前儿童，47.1%患有肥胖症）。测量了血压、人体测量和生化参数，并根据风险因素将儿童分为MU或MH状态。分析了视黄醇、类胡萝卜素、生育酚、总抗氧化能力（TAC）、氧化型低密度脂蛋白以及选定的促炎和内皮损伤生物标志物。进行了针对年龄、性别、招募中心和体重指数进行调整的一般线性模型、偏相关分析和逐步线性回归分析。发现MU儿童的类胡萝卜素和生育酚水平低于MH儿童。与正常体重儿童相比，肥胖的青春期前儿童血浆TAC较低，而肥胖的青春期儿童血浆TAC较高。抗氧化剂和氧化应激生物标志物与几种促炎和内皮损伤生物标志物呈现出新的关联，且存在青春期差异，这支持了在预防儿童代谢疾病时同时考虑抗氧化和氧化应激状态以及青春期的重要性。
