Bungau Alexa Florina, Marin Ruxandra Cristina, Tit Delia Mirela, Bungau Gabriela, Radu Ada, Branisteanu Daciana Elena, Endres Laura Maria
Doctoral School of Biomedical Sciences, Faculty of Medicine and Pharmacy, University of Oradea, 410087 Oradea, Romania.
Department of Preclinical Disciplines, Faculty of Medicine and Pharmacy, University of Oradea, 410073 Oradea, Romania.
Life (Basel). 2025 Jul 28;15(8):1196. doi: 10.3390/life15081196.
Acne vulgaris is a multifactorial inflammatory skin disorder that significantly impairs quality of life and may signal underlying systemic dysfunction, particularly in adult women with treatment-resistant or atypical presentations. This case series presents three clinically and etiologically distinct examples of persistent acne in female patients, each associated with different contributing factors: long-term topical corticosteroid misuse, polycystic ovary syndrome (PCOS), and metabolic syndrome with autoimmune thyroiditis. All cases underwent comprehensive dermatologic evaluation, endocrine/metabolic assessments, and personalized therapeutic interventions, ranging from corticosteroid withdrawal and barrier repair to hormonal modulation and insulin-sensitizing therapy. Clinical progression was monitored for up to six months, revealing favorable responses in all cases, with substantial lesion clearance and improved skin quality. These real-world cases highlight the importance of an integrative, interdisciplinary diagnostic approach in refractory acne and support the need for individualized, long-term management strategies tailored to underlying systemic contributors.
寻常痤疮是一种多因素炎症性皮肤病，严重影响生活质量，可能预示潜在的全身功能障碍，特别是在患有难治性或非典型表现的成年女性中。本病例系列展示了女性患者持续性痤疮的三个临床和病因学上不同的例子，每个例子都与不同的促成因素相关：长期局部滥用皮质类固醇、多囊卵巢综合征（PCOS）以及伴有自身免疫性甲状腺炎的代谢综合征。所有病例均接受了全面的皮肤科评估、内分泌/代谢评估以及个性化治疗干预，范围从停用皮质类固醇和修复皮肤屏障到激素调节和胰岛素增敏治疗。对临床进展进行了长达六个月的监测，结果显示所有病例均有良好反应，皮损大量清除，皮肤质量得到改善。这些实际病例突出了综合、跨学科诊断方法在难治性痤疮中的重要性，并支持需要针对潜在的全身促成因素制定个性化的长期管理策略。
