Santiago Horcajada Marta, Sánchez Barrueco Alvaro, Aragonés Sanzen-Baker William, Díaz Tapia Gonzalo, Moreno Luna Ramón, Villacampa Aubá Felipe, Cenjor Español Carlos, Villacampa Aubá José Miguel
Rhinology Unit, ENT and Cervicofacial Surgery Department, Fundación Jiménez Díaz University Hospital, 28040 Madrid, Spain.
Rhinology Unit, ENT and Cervicofacial Surgery Department, Villalba General University Hospital, 28400 Madrid, Spain.
Life (Basel). 2025 Aug 13;15(8):1281. doi: 10.3390/life15081281.
: Reconstruction of nasal, septal, and nasosinusal defects is challenging when the native mucosa is absent or damaged. Oral mucosal grafts have been proposed as a reconstructive option due to their favorable biological properties, but their use in rhinology remains poorly defined. : To evaluate the clinical efficacy and technical characteristics of oral mucosal grafting for nasal, septal, nasosinusal, and skull base reconstruction. : PubMed, Embase, Web of Science, and Cochrane Library were searched for studies published between January 2005 and May 2025. : We included original human studies (case reports or series) reporting the use of free or pedicled oral mucosal grafts in nasal, septal, nasosinusal, or skull base reconstruction. Non-original studies, animal or preclinical studies, and articles not in English or Spanish were excluded. : One reviewer screened titles, abstracts, and full texts using Rayyan. Methodological quality was assessed using JBI tools for case reports and case series. A narrative synthesis was conducted due to clinical heterogeneity and absence of comparison groups. The resulting assessments were reviewed by the co-authors to confirm accuracy and resolve any potential discrepancies. : Of 467 records identified, 10 studies were included. All were case reports or series involving buccal, palatal, or labial mucosa. Most reported good graft integration, low complication rates, and favorable functional outcomes. No randomized studies or comparative analyses were found. : Included studies had small sample sizes, lacked control groups, and showed heterogeneous methods and follow-up. The certainty of evidence could not be formally assessed. : Oral mucosal grafting is a promising reconstructive option in selected nasosinusal and skull base defects. However, stronger comparative studies are needed to determine its clinical superiority. : This review was not registered in any public database.
当鼻腔、鼻中隔和鼻窦的天然黏膜缺失或受损时，对其进行重建具有挑战性。由于口腔黏膜移植物具有良好的生物学特性，已被提议作为一种重建选择，但其在鼻科学中的应用仍未明确界定。
评估口腔黏膜移植用于鼻腔、鼻中隔、鼻窦和颅底重建的临床疗效和技术特点。
检索了PubMed、Embase、Web of Science和Cochrane图书馆中2005年1月至2025年5月发表的研究。
我们纳入了原始的人体研究（病例报告或系列研究），这些研究报告了在鼻腔、鼻中隔、鼻窦或颅底重建中使用游离或带蒂口腔黏膜移植物的情况。排除非原始研究、动物或临床前研究以及非英文或西班牙文的文章。
一名评审员使用Rayyan筛选标题、摘要和全文。使用JBI工具对病例报告和病例系列进行方法学质量评估。由于临床异质性和缺乏对照组，进行了叙述性综合分析。最终的评估由共同作者进行审核，以确认准确性并解决任何潜在的差异。
在识别出的467条记录中，纳入了10项研究。所有研究均为涉及颊黏膜、腭黏膜或唇黏膜的病例报告或系列研究。大多数研究报告移植物整合良好、并发症发生率低且功能结果良好。未发现随机研究或比较分析。
纳入研究的样本量较小，缺乏对照组，且方法和随访存在异质性。证据的确定性无法进行正式评估。
口腔黏膜移植是治疗某些鼻窦和颅底缺损的一种有前景的重建选择。然而，需要更有力的比较研究来确定其临床优势。
本综述未在任何公共数据库中注册。
