Patti Marisa A, Kivumbi Apollo, Rando Juliette, Song Ashley, Croen Lisa A, Schmidt Rebecca J, Volk Heather E, Lyall Kristen
AJ Drexel Autism Institute, Drexel University, Philadelphia, PA 19104, USA.
Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA.
Int J Environ Res Public Health. 2025 Jul 25;22(8):1174. doi: 10.3390/ijerph22081174.
While gestational Bisphenol A (BPA) exposure has been associated with autism, limited work has focused on dietary sources. Here, we sought to develop a summary metric to capture dietary exposure specifically and test its associations with measured levels, as well as child traits related to autism. Participants ( = 116) were from the Early Autism Risk Longitudinal Investigation (EARLI) Study, which recruited pregnant women who previously had a child diagnosed with autism. Maternal concentrations of BPA were quantified in urine, and dietary sources of BPA were ascertained via food frequency questionnaires during gestation. A novel BPA "dietary burden score" was developed based on reported intake of foods known to contribute to BPA exposure (i.e., canned foods) from a Dietary History Questionnaire modified for pregnancy. Child autism-related traits were assessed via the Social Responsiveness Scale (SRS-2). We examined associations between BPA biomarkers, dietary burden scores, and child SRS scores. Dietary burden scores were weakly correlated with urinary BPA concentrations (R = 0.19, = 0.05) but were not associated with child SRS scores. Our work suggests that more detailed dietary assessments may be needed to fully capture diet-based BPA exposures and address diet as a modifiable source of chemical exposure to reduce associated health impacts of BPA.
虽然孕期双酚A（BPA）暴露与自闭症有关，但针对饮食来源的研究较少。在此，我们试图开发一种汇总指标，专门用于衡量饮食中的BPA暴露情况，并测试其与测量水平以及与自闭症相关儿童特征之间的关联。研究对象（n = 116）来自早期自闭症风险纵向调查（EARLI）研究，该研究招募了之前有一个被诊断为自闭症孩子的孕妇。通过尿液对孕妇的BPA浓度进行定量分析，并在孕期通过食物频率问卷确定BPA的饮食来源。基于对孕期饮食历史问卷中已知会导致BPA暴露的食物（如罐头食品）的报告摄入量，开发了一种新的BPA“饮食负担评分”。通过社会反应量表（SRS - 2）评估儿童与自闭症相关的特征。我们研究了BPA生物标志物、饮食负担评分和儿童SRS评分之间的关联。饮食负担评分与尿BPA浓度呈弱相关（R = 0.19，P = 0.05），但与儿童SRS评分无关。我们的研究表明，可能需要更详细的饮食评估来全面捕捉基于饮食的BPA暴露情况，并将饮食作为一种可改变的化学暴露源加以控制，以减少BPA对健康的相关影响。
