Bogoyavlenskiy Andrey, Alexyuk Madina, Alexyuk Pavel, Omirtayeva Elmira, Zaitseva Irina, Moldakhanov Yergali, Anarkulova Elmira, Berezin Vladimir
Research and Production Center for Microbiology and Virology, 105, Bogenbai Batyr Street, Almaty 050010, Kazakhstan.
Molecules. 2025 Aug 9;30(16):3328. doi: 10.3390/molecules30163328.
The use of vaccines incorporating subunit proteins and viral components has significantly increased in recent decades, emphasizing the need for more effective and modular adjuvants. This study examined saponins from , regarded as one of the most promising plant sources for developing an adjuvant platform using nanocomplex formation. A nanoparticle adjuvant containing saponins from can be used to stimulate a humoral immune response; this ability was demonstrated using a model that included various viral proteins. The humoral immune response enhanced by saponin-containing adjuvants can increase from four to sixteen times, depending on the type of antigen used. Additionally, this response surpasses that triggered by antigens paired with aluminum hydroxide and is comparable to responses induced by adjuvants that contain Quil A. The further investigation of these platforms may yield a broader range of immunostimulants that can enhance vaccine effectiveness.
近几十年来，包含亚单位蛋白和病毒成分的疫苗的使用显著增加，这凸显了对更有效且模块化佐剂的需求。本研究检测了来自[具体植物名称未给出]的皂苷，其被视为利用纳米复合物形成开发佐剂平台最具前景的植物来源之一。含有来自[具体植物名称未给出]皂苷的纳米颗粒佐剂可用于刺激体液免疫反应；使用包含各种病毒蛋白的模型证明了这种能力。含皂苷佐剂增强的体液免疫反应可根据所用抗原类型从四倍增加到十六倍。此外，这种反应超过了与氢氧化铝配对的抗原引发的反应，并且与含有Quil A的佐剂诱导的反应相当。对这些平台的进一步研究可能会产生更广泛的免疫刺激剂，从而提高疫苗效力。
