Nielsen Amalie Ying, Høj Simon, Thomsen Simon Francis, Meteran Howraman
Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.
Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, Rigshospitalet, 2100 Copenhagen, Denmark.
Nutrients. 2024 Nov 28;16(23):4128. doi: 10.3390/nu16234128.
Atopic dermatitis (AD) is a chronic inflammatory skin disease affecting up to 20% of children and 10% of adults worldwide. Current research suggests a correlation between serum vitamin D level and AD severity and that vitamin D supplementation could have a potential therapeutic effect on AD.
To conduct a systematic review and meta-analysis of studies of vitamin D supplementation for disease improvement in children and adults with AD.
PubMed, EMBASE, and Cochrane were searched from 19 April to 20 April 2024. We included randomized controlled trials (RCTs) of patients with AD comparing an intervention group with a control group. The risk of bias of the selected studies was assessed using the Cochrane risk-of-bias tool for randomized trials. All analyses were conducted in R (v4.1.2; R Core Team 2021).
Eleven RCTs with 686 participants were included. The included trials had measured AD severity by using the SCOring Atopic Dermatitis (SCORAD) or the Eczema Area and Severity Index (EASI). Vitamin D supplementation significantly reduced AD severity compared with the control group (standardized mean difference = -0.41, 95% CI: -0.67 to -0.16, = 58%, < 0.01).
Vitamin D supplementation reduces AD severity in children and adults. Larger-scale and longer-term studies are still needed to confirm this conclusion. This study has been registered on PROSPERO (CRD42024535014).
特应性皮炎（AD）是一种慢性炎症性皮肤病，全球高达20%的儿童和10%的成年人受其影响。目前的研究表明血清维生素D水平与AD严重程度之间存在关联，且补充维生素D可能对AD具有潜在治疗作用。
对补充维生素D改善儿童和成人AD的研究进行系统评价和荟萃分析。
于2024年4月19日至20日检索了PubMed、EMBASE和Cochrane数据库。我们纳入了将干预组与对照组进行比较的AD患者随机对照试验（RCT）。使用Cochrane随机试验偏倚风险工具评估所选研究的偏倚风险。所有分析均在R（v4.1.2；R核心团队，2021）中进行。
纳入了11项RCT，共686名参与者。纳入的试验使用特应性皮炎评分（SCORAD）或湿疹面积和严重程度指数（EASI）来衡量AD严重程度。与对照组相比，补充维生素D显著降低了AD严重程度（标准化均数差=-0.41，95%CI：-0.67至-0.16，I²=58%，P<0.01）。
补充维生素D可降低儿童和成人的AD严重程度。仍需要更大规模和更长期的研究来证实这一结论。本研究已在PROSPERO（CRD42024535014）上注册。
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