Göbl Christian, Dardano Angela, Daniele Giuseppe, Tura Andrea
Department of Obstetrics and Gynaecology, Division of Obstetrics and Feto-Maternal Medicine, Medical University of Vienna, 1090 Vienna, Austria.
Department of Clinical and Experimental Medicine, Section of Metabolic Diseases and Diabetes, University of Pisa, 56126 Pisa, Italy.
Nutrients. 2025 Aug 19;17(16):2682. doi: 10.3390/nu17162682.
The present article is an opinion piece mainly based on selected articles in the field of sarcopenia, with possible relevance for pregnancy. Sarcopenia has gained increasing interest in recent years, since it has emerged that sarcopenia may determine significant health consequences, with related substantial health care expenditure. In particular, some studies suggested that sarcopenia may cause increased risk for several diseases, such as type 2 diabetes, obesity, and major cardiovascular events. On the other hand, some studies have reported that the association between sarcopenia and these diseases may be bidirectional. In particular, this holds for type 2 diabetes, because sarcopenia and type 2 diabetes share many etiological and pathogenetic factors, such as insulin resistance, oxidative stress, low-grade chronic inflammation, and adiposity. It is also worth noting that some studies have shown a non-negligible sarcopenia prevalence even in people below 40 years of age, and therefore of reproductive age. Taken together, the above considerations support the hypothesis that sarcopenia may be present in women with gestational diabetes (GDM), which shares common traits with type 2 diabetes. Notably, we hypothesize that sarcopenia may exacerbate GDM-related complications and may influence maternal-fetal outcomes, such as preterm birth or cesarean delivery. Additionally, since pregnancy often presents with insulin resistance independently of any comorbidity, it is plausible that sarcopenia may be present during pregnancy even in cases of normal glycemia. However, there is a lack of data about sarcopenia prevalence in pregnancy and its potential impact on outcomes. Therefore, future studies addressing these aspects are advisable.
本文是一篇观点文章,主要基于肌肉减少症领域的部分选定文章,可能与妊娠相关。近年来,肌肉减少症越来越受到关注,因为已发现肌肉减少症可能会导致严重的健康后果以及相关的大量医疗保健支出。特别是,一些研究表明,肌肉减少症可能会增加患几种疾病的风险,如2型糖尿病、肥胖症和重大心血管事件。另一方面,一些研究报告称,肌肉减少症与这些疾病之间的关联可能是双向的。尤其是2型糖尿病,因为肌肉减少症和2型糖尿病有许多共同的病因和发病因素,如胰岛素抵抗、氧化应激、低度慢性炎症和肥胖。还值得注意的是,一些研究表明,即使在40岁以下、处于生育年龄的人群中,肌肉减少症的患病率也不可忽视。综上所述,上述考虑支持了以下假设:患有妊娠期糖尿病(GDM)的女性可能存在肌肉减少症,GDM与2型糖尿病有共同特征。值得注意的是,我们假设肌肉减少症可能会加剧与GDM相关的并发症,并可能影响母婴结局,如早产或剖宫产。此外,由于妊娠常独立于任何合并症出现胰岛素抵抗,即使在血糖正常的情况下,妊娠期也可能存在肌肉减少症,这是合理的。然而,目前缺乏关于妊娠期间肌肉减少症患病率及其对结局潜在影响的数据。因此,建议未来开展针对这些方面的研究。
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