Li Wei, Sheng Ren-Wang, Cao Mu-Min, Rui Yun-Feng
Department of Spinal Surgery Unit 1 Hanzhong Central Hospital of Shaanxi Province Hanzhong Shaanxi China.
Department of Orthopaedics Tianjin Hospital of Ningqiang Hanzhong Shaanxi China.
Food Sci Nutr. 2024 Oct 21;12(11):8779-8792. doi: 10.1002/fsn3.4550. eCollection 2024 Nov.
Sarcopenia, as a disease characterized by progressive decline of quality, strength, and function of muscles, has posed an increasingly significant threat to the health of middle-aged and elderly individuals in recent years. With the continuous deepening of studies, the concept of gut-muscle axis has attracted widespread attention worldwide, and the occurrence and development of sarcopenia are believed to be closely related to the composition and functional alterations of gut microbiota. In this review, combined with existing literatures and clinical reports, we have summarized the role and impacts of gut microbiota on the muscle, the relevance between gut microbiota and sarcopenia, potential mechanisms of gut microbiota in the modulation of sarcopenia, potential methods to alleviate sarcopenia by modulating gut microbiota, and relevant advances and perspectives, thus contributing to adding more novel knowledge to this research direction and providing certain reference for future related studies.
肌肉减少症是一种以肌肉质量、力量和功能进行性下降为特征的疾病，近年来对中老年人群的健康构成了越来越大的威胁。随着研究的不断深入，肠-肌轴的概念在全球范围内受到广泛关注，肌肉减少症的发生发展被认为与肠道微生物群的组成和功能改变密切相关。在这篇综述中，我们结合现有文献和临床报告，总结了肠道微生物群对肌肉的作用和影响、肠道微生物群与肌肉减少症的相关性、肠道微生物群调节肌肉减少症的潜在机制、通过调节肠道微生物群缓解肌肉减少症的潜在方法以及相关进展和展望，从而为这一研究方向增添更多新知识，并为未来相关研究提供一定参考。
