氯丙嗪通过与三磷酸腺苷相互作用对5-羟色胺积累的影响。
Influence of chlorpromazine on the accumulation of 5-hydroxytryptamine by interaction with ATP.
作者信息
Gasco M R, Trotta M, Gallarate M
出版信息
J Pharm Sci. 1985 Nov;74(11):1188-91. doi: 10.1002/jps.2600741111.
PMID:4087179
Abstract
5-Hydroxytryptamine accumulates at pH 6.0 when ATP is present on one side of an artificial lipoidal barrier. In the presence of chlorpromazine, the diffusion of ATP through the barrier and a decrease in the accumulation of serotonin can be noted. The diffusion rate constants of ATP and serotonin are related to the concentration of chlorpromazine.
摘要
当ATP存在于人工脂质屏障一侧时，5-羟色胺在pH 6.0时会积累。在氯丙嗪存在的情况下，可以观察到ATP通过屏障的扩散以及血清素积累的减少。ATP和血清素的扩散速率常数与氯丙嗪的浓度有关。
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