人血小板芳基硫酸酯酶：鉴定及其破坏慢反应物质A的能力。
Human platelet arylsulphatases: identification and capacity to destroy SRS-A.
作者信息
Metcalfe D D, Corash L M, Kaliner M
出版信息
Immunology. 1979 Aug;37(4):723-9.
Abstract
Arylsulphatases IIA and IIB have been separately identified in human platelets by use of anion exchange chromatography and gel filtration. Arylsulphatase IIA had a molecular weight of 160,000 and a pH optimum of 4.5. Arylsulphatase IIB had a molecular weight of 60,000 and a pH optimum of 5.5. Both arylsulphatases IIA and IIB were inhibited by phosphate and sulphate ions characteristic of this enzyme class. Platelets, upon exposure to ionophore A-23187 or thrombin, discharged arylsulphatase coincident with beta-glcuronidase release. Partially purified platelet arylsulphatase IIB inactivated rat SRS-A.
摘要
通过阴离子交换色谱法和凝胶过滤法，已在人血小板中分别鉴定出芳基硫酸酯酶IIA和IIB。芳基硫酸酯酶IIA的分子量为160,000，最适pH值为4.5。芳基硫酸酯酶IIB的分子量为60,000，最适pH值为5.5。芳基硫酸酯酶IIA和IIB均受到该酶类特有的磷酸根离子和硫酸根离子的抑制。血小板在暴露于离子载体A-23187或凝血酶后，伴随着β-葡萄糖醛酸酶的释放而排出芳基硫酸酯酶。部分纯化的血小板芳基硫酸酯酶IIB可使大鼠SRS-A失活。
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