Phytochemicals as alternative fungicides for controlling plant diseases: A comprehensive review of their efficacy, commercial representatives, advantages, challenges for adoption, and possible solutions.

Fungal infections are responsible for about 70-80% of the losses in agricultural production brought on by microbial diseases. Synthetic fungicides have been employed to manage plant diseases caused by phytopathogenic fungi but their use has been criticized due to unfavorable side effects. As alternative strategies, botanical fungicides have caught the interest of many researchers in recent years. There are numerous experimental studies on the fungicidal activities of phytochemicals against phytopathogenic fungi, but there is not a thorough review article that summarizes these experimental studies. The purpose of this review is therefore to consolidate data from and studies on the antifungal activity of phytochemicals reported by various researchers. This paper describes antifungal activities of plant extracts and compounds against phytopathogenic fungi, approved botanical fungicides, their benefits, obstacles and mitigation strategies. Relevant sources were collected using online data bases such as Google Scholar, PubMed and Science Direct, and comprehensively reviewed for preparation of this manuscript. This review revealed that phytochemicals are effective to manage plant diseases caused by phytopathogenic fungi. Botanical fungicides are endowed with benefits such as resistance inhibition, being ecofriendly, effective, selective, and more affordable compared to synthetic fungicides. However, there are only small number of approved botanical fungicides due to the many challenges that hinder their adoption and utilization for a wider scale production. Farmers' reluctance, lack of standardized formulation techniques, strict legislation, rapid degradation, and other factors hinder their adoption and utilization. The ways to address these challenges include increasing awareness among farmers, conducting more research to identify potential plants with fungicidal properties, standardizing extraction and formulation techniques, implementing the idea of plant breeding to increase bioactive agents, identifying favorable environments for site-specific plant species production, discovering synthetic analogues of the active ingredient to maintain quality standards, establishing reasonable regulation procedures and price points for a quicker market introduction. To put all these into practice, we recommend collaboration of regulatory agencies and researchers from a variety of fields.