Duc Phuong Do, Reeh Solveig, Pöpperl Pauline, Schreiner Tom, Gundling Natascha, Beineke Andreas, Wohlsein Peter, Hoedemaker Martina
Clinic for Cattle, University of Veterinary Medicine Foundation, 30173 Hannover, Germany.
Clinic for Small Animals, University of Veterinary Medicine Foundation, 30559 Hannover, Germany.
Vet Sci. 2025 Aug 1;12(8):728. doi: 10.3390/vetsci12080728.
Since the first emergence of the Bluetongue virus (BTV) in 2006 in Northern Europe, there has been a reported association between BTV Serotype 8 (BTV-8) and brain malformations in calves. The first BTV-3 outbreak in Germany was registered in October 2023. Since then, numbers have increased steadily. In a suckler cow herd in the Lower Saxony region, two Angus calves with clinical signs of diffuse encephalopathy, including ataxia, abnormal gait, and central blindness, were born in autumn 2024. Both calves were submitted for Magnetic Resonance Imaging (MRI) and pathological examination, revealing hydranencephaly and internal hydrocephalus, respectively. BTV-3 was detected in blood and tissue samples of both calves using BTV-specific real-time PCR. The presented findings demonstrate that there seems to be an association between transplacental BTV-3 infections and congenital malformations in calves, as previously reported for BTV-8 and -10.
自2006年蓝舌病毒（BTV）首次在北欧出现以来，已有报道称BTV血清型8（BTV-8）与犊牛脑畸形有关。德国首次爆发BTV-3疫情是在2023年10月。从那时起，病例数量稳步增加。在下萨克森州地区的一个奶牛场中，2024年秋季出生了两头有弥漫性脑病临床症状的安格斯犊牛，这些症状包括共济失调、异常步态和中枢性失明。这两头犊牛均接受了磁共振成像（MRI）和病理检查，分别显示为积水性无脑畸形和内部脑积水。使用BTV特异性实时荧光定量PCR在这两头犊牛的血液和组织样本中检测到了BTV-3。所呈现的研究结果表明，经胎盘感染BTV-3与犊牛先天性畸形之间似乎存在关联，正如之前报道的BTV-8和-10那样。
