Lindblad S, Hedfors E, Malmborg A S
J Rheumatol. 1985 Oct;12(5):900-3.
Intraarticular injections of rifamycin SV were repeated weekly in patients with rheumatic disease with a chronic knee joint effusion. The clinical signs of synovitis were reduced in all, but disappeared in only one. A post injection reaction with transient local pain and effusion appeared at the third or a later injection in all the patients prompting withdrawal of 3. At these later injections local drug retention was shown by parallel determinations of rifamycin SV in synovial fluid and serum. The post treatment synovial fibrosis seen at arthroscopy could possibly explain the drug retention and the post injection inflammatory reaction. Thus, local treatment with rifamycin SV alleviated but rarely abolished synovitis.
对于患有慢性膝关节积液的风湿性疾病患者，每周重复进行关节内注射利福霉素SV。所有患者的滑膜炎临床症状均有所减轻，但只有1例症状消失。所有患者在第三次或之后的注射时出现了伴有短暂局部疼痛和积液的注射后反应，促使3例患者停药。在这些后续注射时，通过同步测定滑液和血清中的利福霉素SV显示存在局部药物潴留。关节镜检查时发现的治疗后滑膜纤维化可能解释了药物潴留和注射后炎症反应。因此，利福霉素SV局部治疗可减轻滑膜炎，但很少能将其消除。
