Sabet-Azad Ramin, Hoath Catherine, Bézay Nicole, Särnefält Anna
The Coalition for Epidemic Preparedness Innovations, Askekroken 11, 0277 Oslo, Norway.
Vaccines (Basel). 2025 Jul 26;13(8):793. doi: 10.3390/vaccines13080793.
Rapid vaccine availability is essential for effective epidemic and pandemic response. Building on the Coalition for Epidemic Preparedness Innovations (CEPI) 100 Days Mission, which aims to have new vaccines ready for initial authorization and manufacturing at scale within 100 days of recognition of a pandemic pathogen, the CEPI has developed a Chemistry, Manufacturing and Controls (CMC) Rapid Response Framework to define technical and logistical CMC requirements to enable rapid vaccine availability. Central to this framework is the availability of adaptable vaccine platforms that can be readily tailored to emerging pathogens. To support strategic decision-making and identify gaps in platform capabilities, CEPI has created the Platform Readiness Dashboard. This tool provides a structured, multi-dimensional initial assessment of platform maturity across six key categories: Adaptability, Compatibility, Suitability, Regulatory, Manufacturing, and Facility Readiness. Each category includes specific technical and operational considerations scored using a color-coded system to reflect outbreak response readiness level. This Dashboard aims to enable vaccine developers, manufacturers, funders, and outbreak response teams to evaluate platform strengths and limitations at any given time, informing funding, preparedness and response activities. By offering a dynamic view of essential platform readiness indicators, the dashboard can communicate progress supporting faster responses to future health emergencies.
快速提供疫苗对于有效应对流行病和大流行至关重要。基于流行病防范创新联盟（CEPI）的100天任务，该任务旨在在识别大流行病原体后的100天内使新疫苗准备好进行初始授权并大规模生产，CEPI制定了化学、制造和控制（CMC）快速响应框架，以定义技术和后勤CMC要求，从而实现疫苗的快速供应。该框架的核心是具备可适应的疫苗平台，这些平台能够很容易地针对新出现的病原体进行定制。为支持战略决策并识别平台能力方面的差距，CEPI创建了平台准备情况仪表盘。该工具对六个关键类别（适应性、兼容性、适用性、监管、制造和设施准备情况）的平台成熟度进行结构化的多维度初步评估。每个类别都包括特定的技术和操作考量因素，并使用颜色编码系统进行评分，以反映应对疫情的准备程度。此仪表盘旨在使疫苗开发者、制造商、资助者和疫情应对团队能够在任何给定时间评估平台的优势和局限性，为资金投入、准备工作和应对活动提供信息。通过提供关键平台准备情况指标的动态视图，该仪表盘可以传达进展情况，支持对未来突发卫生事件做出更快反应。
