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优化艾滋病毒感染者的免疫策略:基本疫苗、疫苗接种率及依从性因素综述

Optimizing Immunization Strategies for Individuals Living with HIV: A Review of Essential Vaccines, Vaccine Coverage, and Adherence Factors.

作者信息

Würfel Lina M, Potthoff Anja, Skaletz-Rorowski Adriane, Nambiar Sandeep, Abu Rached Nessr

机构信息

Walk In Ruhr [WIR]-Centre for Sexual Health and Medicine, Große Beckstraße 12, 44787 Bochum, Germany.

Interdisciplinary Immunological Center, Centre for Sexual Health and Medicine, Department of Dermatology, Venerology und Allergology, Ruhr University Bochum, Große Beckstraße 12, 44787 Bochum, Germany.

出版信息

Vaccines (Basel). 2025 Jul 28;13(8):798. doi: 10.3390/vaccines13080798.

DOI:10.3390/vaccines13080798
PMID:40872885
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12390374/
Abstract

Human immunodeficiency virus (HIV) infection remains a major challenge in global health. In recent years, vaccines have emerged as an important tool for the treatment and prevention of HIV-related complications. This review article addresses the evolving landscape of vaccines for people living with HIV (PLWH), evaluating current vaccination strategies for standard vaccines and travel vaccines in PLWH compared to the general population and offering a summary of the current recommended vaccines. It evaluates studies for vaccine effectiveness and safety and discusses methods to improve vaccination rates among PLWH. Systematic research was carried out using keywords. We address the current state of knowledge and highlight areas for future research and development.

摘要

人类免疫缺陷病毒(HIV)感染仍然是全球卫生领域的一项重大挑战。近年来,疫苗已成为治疗和预防HIV相关并发症的重要工具。这篇综述文章探讨了HIV感染者(PLWH)疫苗的不断变化的格局,评估了与普通人群相比PLWH中标准疫苗和旅行疫苗的当前接种策略,并总结了当前推荐的疫苗。它评估了疫苗有效性和安全性的研究,并讨论了提高PLWH接种率的方法。使用关键词进行了系统研究。我们阐述了当前的知识状态,并突出了未来研究和开发的领域。

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本文引用的文献

1
A meta-analysis of immunogenicity and safety of two versus single-doses of influenza A (H1N1) vaccine in person living with HIV.一项荟萃分析显示,与单剂量相比,两种剂量的甲型流感(H1N1)疫苗在 HIV 感染者中的免疫原性和安全性。
Int J STD AIDS. 2024 Apr;35(5):326-336. doi: 10.1177/09564624231220424. Epub 2023 Dec 12.
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Vaccine development: Current trends and technologies.疫苗研发:当前趋势与技术。
Life Sci. 2024 Jan 1;336:122331. doi: 10.1016/j.lfs.2023.122331. Epub 2023 Dec 7.
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Mpox: Clinical Outcomes and Impact of Vaccination in People with and without HIV: A Population-Wide Study.猴痘:HIV感染者和非HIV感染者的临床结局及疫苗接种影响:一项全人群研究
Microorganisms. 2023 Nov 3;11(11):2701. doi: 10.3390/microorganisms11112701.
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Increasing hepatitis B vaccination coverage and decreasing hepatitis B co-infection prevalence among people with HIV-1 in Germany, 1996-2019. Results from a cohort study primarily in men who have sex with men.在德国,1996 年至 2019 年间,通过增加乙肝疫苗接种覆盖率和降低 HIV-1 感染者中乙肝共感染的流行率,取得了成果。这是一项主要针对男男性行为者的队列研究的结果。
HIV Med. 2024 Feb;25(2):201-211. doi: 10.1111/hiv.13554. Epub 2023 Oct 2.
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Immunogenicity of tetanus, diphtheria and acellular pertussis vaccination among pregnant women living with and without HIV.孕妇合并与不合并 HIV 时接种破伤风、白喉和无细胞百日咳疫苗的免疫原性。
AIDS. 2023 Dec 1;37(15):2305-2310. doi: 10.1097/QAD.0000000000003731. Epub 2023 Oct 3.
6
Viral blips and virologic failures following mpox vaccination with MVA-BN among people with HIV.HIV感染者接种MVA-BN痘苗疫苗后的病毒波动和病毒学失败
AIDS. 2023 Dec 1;37(15):2365-2369. doi: 10.1097/QAD.0000000000003733. Epub 2023 Sep 28.
7
Mpox in people with past infection or a complete vaccination course: a global case series.既往感染或全程接种疫苗人群中的猴痘:全球病例系列研究。
Lancet Infect Dis. 2024 Jan;24(1):57-64. doi: 10.1016/S1473-3099(23)00492-9. Epub 2023 Sep 4.
8
Immunogenicity and reactogenicity of yellow fever vaccine in people with HIV.黄热病疫苗在 HIV 感染者中的免疫原性和反应原性。
AIDS. 2023 Dec 1;37(15):2319-2329. doi: 10.1097/QAD.0000000000003696. Epub 2023 Aug 23.
9
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