核黄素作为药物依从性的一种追踪指标。

Riboflavin as a tracer of medication compliance.

作者信息

Dubbert P M, King A, Rapp S R, Brief D, Martin J E, Lake M

出版信息

J Behav Med. 1985 Sep;8(3):287-99. doi: 10.1007/BF00870315.

Abstract

Three experiments were conducted to evaluate the accuracy of urine ultraviolet fluorescent tests for riboflavin, which has been used as a tracer for medication compliance in several clinical drug trials. Observer accuracy in discriminating riboflavin-positive or negative urine samples was found to vary with the method of observation, dose of riboflavin, observer experience, and time postingestion. The results showed that, while the 5-mg dose used in previous clinical trials was too small to permit reliable assessment of compliance, larger doses of riboflavin could produce nearly 100% accuracy for minimally trained observers who used a matching-to-sample observation procedure. The findings are discussed in terms of the potential clinical and research applications of this type of simple but reliable compliance assessment procedure.

摘要

进行了三项实验以评估尿液紫外线荧光试验检测核黄素的准确性，核黄素在多项临床药物试验中被用作药物依从性的示踪剂。结果发现，观察者辨别核黄素阳性或阴性尿液样本的准确性会因观察方法、核黄素剂量、观察者经验以及摄入后时间的不同而有所差异。结果表明，虽然先前临床试验中使用的5毫克剂量过小，无法可靠地评估依从性，但对于使用样本匹配观察程序的训练不足的观察者而言，更大剂量的核黄素可产生近100%的准确率。本文根据这种简单但可靠的依从性评估程序的潜在临床和研究应用对这些发现进行了讨论。